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Description
  • The main goal of our project is to extend knowledge about molecular mechanisms involved in glioblastoma carcinogenesis and invasivness by analysis of microRNA expression profiles in primary tumors and use our findings for prediction of response to temozolomide and immunotherapy in patients with glioblastoma. (en)
  • Hlavním cílem našeho projektu je přispět k molekulární charakterizaci glioblastoma multiforme pomocí analýzy expresních profilů mikroRNA v primárních tumorech a využít naše poznatky k predikci odpovědi na moderní léčebné postupy založené na temozolomidu nebo buněčné imunoterapii u pacientů s glioblastomem.
Title
  • Identification and functional characterization of microRNAs with predictive significance in patients with glioblastoma (en)
  • Identifikace a funkční charakterizace mikroRNA s prediktivním významem u pacientů s glioblastomem
skos:notation
  • NT11214
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  • glioblastoma multiforme; microRNA; diagnosis; temozolomide; prediction; prognosis (en)
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  • In glioblastoma samples was identified 108 increased and 108 decreased miRNAs. Set of 6 miRNA was significantly associated with survival and time to progression, it is an independent factor predicting response to treatment with 78% sensitivity and specif (en)
  • Ve vzorcích glioblastomu bylo identifikováno 108 zvýšených a 108 snížených miRNA. Sada 6 miRNA je významně sdružena s přežitím i dobou do progrese onemocnění, jedná se o nezávislý faktor predikující odpověď na léčbu se 78% senzitivitou i specifitou. (cs)
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  • glioblastoma multiforme
  • diagnosis
  • microRNA
  • prediction
  • temozolomide
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