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  • Mechanisms of induction of mucosal protective immunity by intranasal administration of autoantigens using bioptic material of human nasal mucosa and mouse models of type 1. diabetes and ulcerative colitis. Role of NALT (Nasal associated lymphoid tissue) and its draining mucosal lymph nodes (ACLN) in the development of mucosal regulatory responses after i.n. administration of autoantigens. Antigen trafficking and kinetics of induction of regulatory cells after i.n. vaccination. Nasal mucosa-induced subsets of regulatory cells and their functional capacity to prevent autoimmune diseases” ulcerative colitis and type 1 diabetes. (en)
  • Mechanismy indukce slizniční tolerance po intranasální aplikaci autoantigenů na bioptickém materiálu nosní sliznice a myším modelech diabetu 1. typu a ulcerozní kolitidy. Úloha NALTu (Nasal Associated Lymphoid Tissue) a spádových povrchových krčních lymfatických uzlin (ACLN) na vývoj slizniční protektivní imunity po i.n. aplikaci autoantigenů. Distribuce antigenu a kinetika indukce regulačních buněk po intranasální vakcinaci. Regulační buňky indukované na úrovni nosní sliznice a jejich funkční kapacita v prevenci autoimunitních onemocnění: ulcerozní kolitidy a diabetu 1. typu.
Title
  • Intranasal vaccination in prevention of autoimmune diseases (en)
  • Intranasální vakcinace v prevenci autoimunitních onemocnění
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  • mucosal tolerance; intranasal vaccination; autoimmune disease; ulcerative colitis; type 1 diabetes; prevention; NALT (en)
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  • An approach of isolation of the NALT cells was developed. This compartment of the immune system plays an important role in immune response induction. Intranasal exposure to antigens modifies experimentally induced diabetes and colitis in mice. (en)
  • Podařilo se vypracovat metodiku izolace buněk NALT.Tato oblast imunitního systému hraje důležitou roli v indukci imunitní odpovědi. Nasální podání antigenů též modifikuje průběh experimentálně indukovaného diabetu a kolitidy u myší. (cs)
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  • prevention
  • ulcerative colitis
  • autoimmune disease
  • intranasal vaccination
  • type 1 diabetes
  • mucosal tolerance
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