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Description
  • To establish the prevalence of NPSLE (active or previous manifestations) and cognitive dysfunction in Czech SLE patients and to detemine its association with blood brain barrier disruption, evaluated using brain MRI and/or protein analysis of cerebrospinal fluid, and autoantibodies presence (anti-dsDNA, anti-P, antineuronal and antiphospholipid antibodies) (en)
  • Stanovit prevalenci neuropsychiatrikého postižení u SLE (aktivní i proběhlé anamnesticky) a zejména kognitivní dysfunkce u populace českých nemocných se SLE a stanovit její asociaci s poruchou hematoencefalické bariéry, hodnocené pomocí MR mozku, případně pomocí vyšetření proteinových frakcí likvoru, a přítomností některých autoprotilátek (anti-dsDNA, anti-P, antineuronální protilátky).
Title
  • Cognitive dysfunction in systemic lupus erythematosus and its relation to blood brain barrier damage (en)
  • Kognitivní dysfunkce u systémového lupus erythematosus a její vztah k poruše hematoencefalické bariéry
skos:notation
  • NR9290
http://linked.open...avai/cep/aktivita
http://linked.open...kovaStatniPodpora
http://linked.open...ep/celkoveNaklady
http://linked.open...datumDodatniDoRIV
http://linked.open...i/cep/druhSouteze
http://linked.open...ep/duvernostUdaju
http://linked.open.../cep/fazeProjektu
http://linked.open...ai/cep/hlavniObor
http://linked.open...hodnoceniProjektu
http://linked.open...vai/cep/kategorie
http://linked.open.../cep/klicovaSlova
  • neuropsychiatric lupus; systemic lupus erythematosus; cognitive dysfunction; blood brain barrier damage (en)
http://linked.open...ep/partnetrHlavni
http://linked.open...inujicichPrijemcu
http://linked.open...cep/pocetPrijemcu
http://linked.open...ocetSpoluPrijemcu
http://linked.open.../pocetVysledkuRIV
http://linked.open...enychVysledkuVRIV
http://linked.open...lneniVMinulemRoce
http://linked.open.../prideleniPodpory
http://linked.open...iciPoslednihoRoku
http://linked.open...atUdajeProjZameru
http://linked.open.../vavai/cep/soutez
http://linked.open...usZobrazovaneFaze
http://linked.open...ai/cep/typPojektu
http://linked.open...ep/ukonceniReseni
http://linked.open...ep/zahajeniReseni
http://linked.open...jektu+dodavatelem
  • Prokázána vysoká prevalence KD u pacientů se SLE,zejména u pozitivity antikardiolipinových protilátek. Vyšší hodnota SLEDAI a SLICC byla u pacientů s KD oproti pacientům bez KD. Neprokázána asociace KD s poruchou HEB. (cs)
  • We found high prevalence of CD in SLE patients,especially in patients with antiphospholipid antibodies.Higher value of SLEDAI and SLICC was found in patients with CD contrary to patients without CD.There was no association of CD with HEB impairment. (en)
http://linked.open...tniCyklusProjektu
http://linked.open.../cep/klicoveSlovo
  • cognitive dysfunction
  • systemic lupus erythematosus
  • neuropsychiatric lupus
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