About: HDL metabolism and its changes in patients with the meabolic syndrome after firate therapy     Goto   Sponge   NotDistinct   Permalink

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Description
  • In patients with metabolic syndrome lipid parametres, namely HDL partices, will be followed before and after initiation of the fibrate therapy. The risk of atherosclerosis will be estimated using new markers of atherogenesis. The molecular basis of fibrate action in dyslipidaemia accompanying metabolic syndrome will be evaluated determining the expression of genes for LCAT and CETP after fibrate therapy initiation. (en)
  • U pacientů s matabolickým syndromem budou sledovány lipidové parametry se zaměřením na HDL částice před a po léčbě fibrátem a bude u nich stanovováno aterogenní riziko pomocí nových ukazatelů aterogeneze. Bude sledován mechanismus účinku fibrátů u dyslipidémie provázející metabolický syndrom sledováním změn exprese genů pro LCAT a CETP.
Title
  • HDL metabolism and its changes in patients with the meabolic syndrome after firate therapy (en)
  • Metabolismus HDL a jeho změny u pacientů s metabolickým syndromem při léčbě fibrátem
skos:notation
  • NR8328
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  • metabolic syndrome; fractional esterification rate; atherogenic index of plasma; fibrates; gene expression (en)
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  • Řešení splnilo anotované cíle ve schváleném termínu. Výsledky publikovány s dedikací tomuto projektu IGA MZ + dalším grantům, 5x originální práce v časopisech s IF, řada dalších prací a abstrakt z kongresů. (cs)
  • Solution of the project fulfilled annotated goals in appropriate term. Results were published with dedication to no of this project IGA MZ + other projects in journals with known IF, in a number of other journals and abstracts from conferences. (en)
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  • metabolic syndrome
  • atherogenic index of plasma
  • fibrates
  • fractional esterification rate
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