About: The study of (18F) fluorothymidine preparation and verification of its pharmacokinetics in the PET studies     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

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Description
  • Study of the 3´- deoxy-3´-(18F) fluorothymidine (FJFLT) preparation and finding a suitable synthesis precursor including the synthesis parameters optimization. Completion of the study of an irradiation target for sufficient production of fluorine. Development of methods of (18F) FLT quality control, above all of the radiochemical and chemical purity of the synthesized product. Performing the introductory biodistribution study including the distribution visualizing on a PET camera. (en)
  • Studium přípravy 3´- deoxy ´- (18F) fluorothymidin (18F) FLT a nalezení vhodného prekuzoru pro syntézu ( 18F) FLT). Vývoj metod kontroly kvality (18F)FLT, především kontroly radiochemické čistoty a chemické čistoty syntetizovaného produktu. Provedení úvodní biodistribuční studie včetně zobrazení distribuce na PET kameře.
Title
  • The study of (18F) fluorothymidine preparation and verification of its pharmacokinetics in the PET studies (en)
  • Studium přípravy (18F) fluorothymidinu a ověření jeho farmakokinetiky v PET studiích.
skos:notation
  • NL7688
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  • PET radiopharmaceuticals;(18F) fluorthymidin;Biodistribution study;Synthesis efficiency;Nucleofolic substitution;Quality control (en)
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  • The design and optimization of procedure for synthesis of [18F]FLT including a suitable precursor were worked out within the project. Methods for determination of chemical and radiochemical purity were developed and biological behavior was verified. (en)
  • Hlavním výsledkem řešení projektu je vypracování a optimalizace postupu pro syntézu [18F]FLT včetně nalezení vhodného prekurzoru. Vypracovány metody pro kontrolu chemické a radiochemické čistoty přípravku a ověřeno jeho biologické chování. (cs)
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http://linked.open.../cep/klicoveSlovo
  • (18F) fluorthymidin
  • Biodistribution study
  • Nucleofolic substitution
  • PET radiopharmaceuticals
  • Synthesis efficiency
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