About: Hybrid gene TEL/AML1 and Asparagine Synthetase gene in pathogenesis of childhood leukemias.     Goto   Sponge   NotDistinct   Permalink

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Description
  • Proposed study will concentrate on relationship between TEL/AML1 hybrid gene, L-Asparaginase and Asparagine Synthetase regulation in leukaemic cells. We will employ modern approaches including quantitative real-time PCR and RNA interference. We will study the mechanisms of Asparagine Synthetase expression regulation, Asparagine Synthetase activity, relationship between TEL/AML1 and Asparagine Synthetase exúression and resistance to L-asparaginase. (en)
  • Navrhovaná studie se zaměří na vztrah mezi hybridním genem TEL/AML1, L-asparaginasou a regulací genu pro asparagin synthetasu v leukemických buńkách. Budeme využívat moderní přístupy včetně kvantitativní PCR v reálném čase a RNA interference. Budeme studovat mechanismy regulace exprese asparagin synthetasy, aktivitu asparagin synthetasy, vztah mezi TEL/AML1 a expresí asparagin synthetasy a resistencí na L-asparaginasu.
Title
  • Hybrid gene TEL/AML1 and Asparagine Synthetase gene in pathogenesis of childhood leukemias. (en)
  • Hybridní gen TEL/AML1 a gen pro asparagin synthetasu v patogenesi dětských leukemií
skos:notation
  • NE7433
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  • L-Asparaginase;childhood ALL;asparagine Synthetase;TEL/AML1;RQ-PCR;RNA interference;gene expression;flow cytometry (en)
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  • Different intracellular synthesis of asparagine and glutamine in TEL/AML1(+) cells causes better sensitivity to L-Asparaginase.This divergence is manifested by defferent gene expression of Asparagin Synthetase and Glutamate Dehydrogenase. (en)
  • Zvýšená citlivost TEL/AML1(+)buněk na L-Asparaginázu je ovlivněna odlišnou intracelulární syntézou asparaginu a glutaminu v porovnání s jinými leukemickými buňkami.Projevuje se to odlišnou expresí genu pro asparagin synteázu a glutamát dehydrogenázu. (cs)
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  • gene expression
  • TEL/AML1
  • RNA interference
  • childhood ALL
  • L-Asparaginase
  • RQ-PCR
  • asparagine Synthetase
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