In transgenic rats TGR (mRen2)27 hyperproducing renin, the possible role of endothelin (ET) in the mechanism of their hypertension will be studied by the use of a chronic administration of ET receptor antagonist, bosentan. (en)
Na transgenních potkanech kmene TGR (mRen2)27, které hyperprodukují renin, bude studována event.úloha endothelinu v mechanismu vzniku hypertenze pomocí receptorového antagonisty pro ET-bosentanu.
Bosentan;Endothelin;Hypertension;Transgenic rats hyperproducing;TGR(mRen2)27;Hypertension in transgenic rat;Renal function in TGR(mRen2);The role of salt in the diet (en)