About: The role of post-translational modification in DNA repair and recombination: Meiosis, SUMOylation and Zip3 protein     Goto   Sponge   NotDistinct   Permalink

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Description
  • The goal of the project is to understand the function of SUMO protein in the homologous recombination, which is the essential process for meiosis and error-free DNA repair of double-strand breaks. (en)
  • Cílem projektu je pochopení funkce SUMO proteinu v procesu homologní rekombinace, který je nezbytnou součástí meiotického dělení buněk umožňujícího pohlavní rozmnožování a zároveň je jedním z klíčových mechanismů zajišťujících opravu poškozené DNA.
Title
  • The role of post-translational modification in DNA repair and recombination: Meiosis, SUMOylation and Zip3 protein (en)
  • Vliv post-translačních modifikací na DNA opravu a rekombinaci.
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  • ME10048
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  • SUMOylation; DNA repair; recombination; meiosis (en)
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  • V rámci charakterizování vlivu sumoylace na vlastnosti proteinu Lif1 jsme identifikovali lysin, na kterém dochází ke konjugaci, a testovali vliv DNA a E3 ligáz na jeho sumoylaci. Analýza pomocí 2-hybridního systému ukázala vliv sumoylace na oligomerizaci Lif1 proteinu a naše výsledky naznačují, že sumoylace Lif1 snižuje účinnost nehomologního spojování konců a představuje nový regulační element. (cs)
  • During characterization of the role of Lif1 sumoylation we have identified main conjugation lysine and tested the effect of DNA and E3 ligases on its sumoylation. Using 2-hybrid system we have shown the effect of sumoylation on the oligomerization of Lif1 protein and our data indicate that sumoylation down-regulates the efficiency of end joining and represents a new regulatory element. (en)
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  • SUMOylation
  • DNA repair
  • recombination
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