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  • The aim of the MultiGRAN project is to develop, implement and validate a comprehensive methodology for the analysis of design granulation processes that would span all relevant length-scales: (i) the single-particle length-scale (wetting kinetics), (ii) the granule length-scale (evolution of granule structure due to particle collisions), and (iii) the process length-scale, describing the overall population. The methodology will combine both experiments and computer simulations, and it will follow the 'bottom-up' approach. The purpose of the proposed collaboration is to bring together two leading experts in the field of granulation with complementary skills - prof. Rohit Ramachandran from Rutgers University, who has developed unique methods for the solution of multi-dimensional population balance models of granulation and prof. Frantisek Stepanek from the Institute of Chemical Technology, Prague, who has developed methods for micro-scale granule characterisation and modelling of granule microstructure (en)
  • Cílem projektu je vyvinout a otestovat metodologii pro víceúrovňové modelování procesu granulace, který by umožnil na základě znalosti materiálových vlastností vstupních surovin a znalosti operačních parametrů procesu spolehlivě predikovat vlastnosti výsledných granulí - konkrétně distribuci velikosti, distribuci složení a porozitu. Vyvinutý model by pak měl sloužit k racionálnímu návrhu granulačních procesů a identifikaci rozsahu operačních parametrů zajišťujících jejich robustní (tj. málo náchylné k chybám) provozování.
Title
  • Multi-scale analysis and design of granulation processes (en)
  • Víceúrovňová analýza a návrh granulačních procesů
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  • LH12115
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  • granulation; particle technology; process engineering; pharmaceutical engineering; mathematical modeling and simulation (en)
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  • granulation
  • particle technology
  • pharmaceutical engineering
  • process engineering
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