About: Genetic determinants of interstitial fibrosis and coronary microvascular remodelation     Goto   Sponge   NotDistinct   Permalink

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Description
  • We will use histomorphometric analyses to determine the presence and extent of coronary microvascular remodeling and myocardial fibrosis in the BXH/HXB recombinant inbred strains derived from the spontaneously hypertensive rats (SHR) and Brown Norway (BN) rats. Using linkage and correlation analyses combined with gene expression profiles in left ventricles, sequencing as well as in vivo functional studies with selected candidate genes, we will identify at the molecular level genetic determinants of coronary microvascular remodeling and myocardial fibrosis. (en)
  • Pomocí histomorfometrických analýz stanovíme přítomnost a rozsah koronární mikrovaskulární remodelace a myokardiální fibrózy u BXH/HXB rekombinantních inbredních kmenů odvozených od spontánně hypertenzních (SHR) and Brown Norway (BN) potkanů. Pomocí vazebných a korelačních analýz s profily genové exprese stanovenými v levé komoře srdeční, sekvenačních a in vivo funkčních analýz odhalíme na molekulární úrovni genetické determinanty koronární mikrovaskulární remodelace a myokardiální fibrózy.
Title
  • Genetic determinants of interstitial fibrosis and coronary microvascular remodelation (en)
  • Genetické determinanty intersticiální fibrózy a koronární mikrovaskulární remodelace
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  • LH11049
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  • coronary microvascular remodeling; fibrosis; spontaneously hypertensive rat; recombinant inbred strains; genes (en)
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  • recombinant inbred strains
  • fibrosis
  • spontaneously hypertensive rat
  • coronary microvascular remodeling
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