About: Polymorphisms in the MTHFR gene: susceptibility to colorectal cancer and role in the response to therapy     Goto   Sponge   NotDistinct   Permalink

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Description
  • Polymorphisms in several genes have been indicated as possible susceptibility factors for sporadic colorectal cancer (CRC). Moreover, identification of subgroups of patients that differ in their prognosis and response to treatment suggests that inter-individual differences in the toxicity and response to anticancer therapies is due to their genetic profile. We will investigate the role of polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and in thymidylate synthase (TS) in a population of CRC cases and controls as predictive markers of CRC and response to the therapy. The response to CRC treatment will be evaluated in relation to the role of the analyzed polymorphisms on the selected groups of patients receiving 5-fluorouracil-based chemotherapy and external beam radiotherapy. Present project may contribute to the understanding CRC susceptibility and individual response to chemotherapy and prognosis of patients.  (en)
  • Cíle předkládaného projektu: a) zkoumat úlohu genetických polymorfizmů v genech MTHFR a TS u populací CRC pacientů a kontrolních skupin jako prediktivních markerů CRC b) zhodnocení možného vztahu mezi uvedenými polymorfizmy v souvislosti s odpovědí na léčbu CRC
Title
  • Polymorphisms in the MTHFR gene: susceptibility to colorectal cancer and role in the response to therapy (en)
  • Genetické polymorfizmy v genu MTHFR: modulace rizika CRC a vliv na vnímavost k terapii
skos:notation
  • GP305/09/P194
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  • kolorectalni karcinom, polymorphizmus, MTHFR, chemoterapie (en)
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  • The project was excellent, both in terms of expertise and in terms of disbursement of funds. (en)
  • Řešení projektu proběhlo na vynikající úrovni, a to jak z hlediska odborného tak i z hlediska čerpání finančních prostředků. (cs)
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  • MTHFR
  • polymorphizmus
  • kolorectalni karcinom
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