About: Large-scale identification of genes responsible for the formation of solid tumours     Goto   Sponge   NotDistinct   Permalink

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Description
  • Genetic and epigenetic changes responsible for the formation and progression of solid tumours are rather complex and difficult to analyze as they usually accumulate over a long time. The chicken renal tumour experimentally induced by retroviruses of myeloblastosis-associated virus (MAV) type, can significantly facilitate analysis of the whole process of solid tumour formation and progression. This model enables precise identification of genetic changes in clonal experimental tumours. In the proposed project we want to take up and expand our current work on this model in which we validated the usefulness of the model for identification of potential human cancer-related genes. Furthermore, in different solid human tumours, we will search for the expression products of human homologs of identified genes. We believe that our approach provides new information on genetic aberrations underlying formation of solid tumours as well as data with diagnostic and prognostic values. (en)
  • V širokém měřítku identifikovat geny a jejich změny, které způsobí vznik a rozvoj experimentálních ptačích ledvinných nádorů. Výsledky využít pro stanovení expresních produktů homologních genů v lidských nádorech. Vytipovat a ověřit výsledky s diagnostickým a prognostickým potenciálem.
Title
  • Large-scale identification of genes responsible for the formation of solid tumours (en)
  • Identifikace velkého počtu genů zodpovědných za tvorbu solidních nádorů
skos:notation
  • GA301/09/1727
http://linked.open...avai/cep/aktivita
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  • geny s nádorotvorným potenciálem; inserční mutagenesa; kuřecí nefroblastom (en)
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  • inserční mutagenesa
  • geny s nádorotvorným potenciálem
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