About: Novel treatment of genetically determined metabolic disease, type 1 diabetes, using an immunotherapeutical approach.     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

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Description
  • The aim of the proposed project is a characterization of genetical profile of patients with type 1 diabetes mellitus (T1D) and induction of specific immune tolerance. Immunotherapeutical approaches could achieve complete cure of T1D or reverse unfavourable development of this serious disease (and prevent cardiovascular and metabolical complications of the patients). Project is focused on creation of laboratory procedure which would lead to clinical application of immunological preparation based on genetically modified tolerogenic T lymphocytes and dendritic cells. This therapeutical approach could be also original medical treatment for wider spectra of autoimmune disease such as multiple sclerosis and rheumatoid arthritis. (en)
  • Cílem projektu je charakteristika genetického profilu pacientů s diabetes mellitus 1. typu a navození specifické imunitní tolerance vůči diabetogenním antigenům metodami genového inženýrství a imunologie.
Title
  • Novel treatment of genetically determined metabolic disease, type 1 diabetes, using an immunotherapeutical approach. (en)
  • Studium léčebných možností diabetes mellitus 1. typu jako geneticky determinované metabolické choroby s využitím nových imunoterapeutických postupů
skos:notation
  • 2B08066
http://linked.open...avai/cep/aktivita
http://linked.open...kovaStatniPodpora
http://linked.open...ep/celkoveNaklady
http://linked.open...datumDodatniDoRIV
http://linked.open...i/cep/druhSouteze
http://linked.open...ep/duvernostUdaju
http://linked.open.../cep/fazeProjektu
http://linked.open...ai/cep/hlavniObor
http://linked.open...hodnoceniProjektu
http://linked.open...vai/cep/kategorie
http://linked.open.../cep/klicovaSlova
  • Type 1 diabetes; immunotherapy; autoimmunity; genetical determination; Foxp3. (en)
http://linked.open...ep/partnetrHlavni
http://linked.open...inujicichPrijemcu
http://linked.open...cep/pocetPrijemcu
http://linked.open...ocetSpoluPrijemcu
http://linked.open.../pocetVysledkuRIV
http://linked.open...enychVysledkuVRIV
http://linked.open...lneniVMinulemRoce
http://linked.open.../prideleniPodpory
http://linked.open...iciPoslednihoRoku
http://linked.open...atUdajeProjZameru
http://linked.open.../vavai/cep/soutez
http://linked.open...usZobrazovaneFaze
http://linked.open...ai/cep/typPojektu
http://linked.open...ep/ukonceniReseni
http://linked.open.../cep/vedlejsiObor
http://linked.open...ep/zahajeniReseni
http://linked.open...jektu+dodavatelem
  • V průběhu řešení projektu byly plněny anotované metodiky, a to jak v plánovaných termínech, tak i v odborné náplni aktivit. Předložené závěrečné řešení je příkladem úspěšné spolupráce vysokých škol a Akademie věd s praxí. Byla získána řada významných výsledků. (cs)
  • In the course of the research plan solving the annotated methodologies have been thoroughly fulfilled, and that related to the scheduled terms as well as expert scope of activities. Submitted final solution is the example of successful cooperation of universities and Academy of Sciences with the practice. A number of significant results has been achieved. (en)
http://linked.open...tniCyklusProjektu
http://linked.open.../cep/klicoveSlovo
  • Type 1 diabetes
  • autoimmunity
  • immunotherapy
  • genetical determination
is http://linked.open...vavai/cep/projekt of
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