About: New approaches to study the toxicity of the air pollution and their contribution to assess limits for selected pollutants.     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

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Description
  • The project deals with the analysis and clarification of mechanisms of adverse effects caused by human exposure to xenobiotics in the ambient air with special attention paid to carcinogenic polycyclic aromatic hydrocarbons (c-PAHs) bound onto respirable dust particles. The changes in the gene expression and various biomarkers will be identified in model systems in vitro and in lymphocytes of subjects exposed to polluted air. The limit values for benzo(a)pyrene (B[a]P) as a major c-PAH representative and dust particles PM2.5 will be suggested by comparison of the results for various localities and sampling seasons. These limit values might be regarded as safe from the point of view of the biological effect studied. (en)
  • S použitím nových metod toxikogenomiky a molekulární epidemiologie definovat kritické koncentrace vybraných toxických látek (B[a]P, PM2.5) ve vnějším ovzduší, které již vyvolávají významné biologické změny v lidském organismu.
Title
  • New approaches to study the toxicity of the air pollution and their contribution to assess limits for selected pollutants. (en)
  • Nové přístupy ke studiu toxicity ovzduší a jejich příspěvek ke stanovení limitních hodnot vybraných polutantů
skos:notation
  • 2B08005
http://linked.open...avai/cep/aktivita
http://linked.open...kovaStatniPodpora
http://linked.open...ep/celkoveNaklady
http://linked.open...datumDodatniDoRIV
http://linked.open...i/cep/druhSouteze
http://linked.open...ep/duvernostUdaju
http://linked.open.../cep/fazeProjektu
http://linked.open...ai/cep/hlavniObor
http://linked.open...hodnoceniProjektu
http://linked.open...vai/cep/kategorie
http://linked.open.../cep/klicovaSlova
  • air pollution; PAH; VOC; oxidative stress; gene expression; genetic susceptibility (en)
http://linked.open...ep/partnetrHlavni
http://linked.open...inujicichPrijemcu
http://linked.open...cep/pocetPrijemcu
http://linked.open...ocetSpoluPrijemcu
http://linked.open.../pocetVysledkuRIV
http://linked.open...enychVysledkuVRIV
http://linked.open...lneniVMinulemRoce
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http://linked.open...jektu+dodavatelem
  • Achievements and progress of the project correspond with the contract. The planned targets were met. (en)
  • Dosažené výsledky a průběh řešení projektu odpovídají smlouvě. Plánované cíle byly splněny. (cs)
http://linked.open...tniCyklusProjektu
http://linked.open.../cep/klicoveSlovo
  • air pollution
  • PAH
  • VOC
  • gene expression
  • oxidative stress
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