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Description
  • introduction of suitable in vivo and in vitro methods for prediction and evaluation of pharmacokinetics and pharmacodynamic properties of substances at hepatic damage (en)
  • zavedení vhodné in vitro a in vivo metody pro predikci a hodnocení farmakokinetických a farmakodynamických vlastností látek při jaterním poškození
Title
  • Changes in pharmacokinetics and pharmacodynamics of drugs in the presence of impaired liver function (en)
  • Sledování změn farmakokinetiky a farmakodynamiky léčiv při poškozené funkci jater
skos:notation
  • 1P05OC062
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  • pharmacokinetics and pharmacodynamics; drugs; of impaired liver function; in vivo; in vitro method (en)
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  • Změny v expresi transportních proteinů při experimentální cholsetáze mohou vyvolat změny kinetiky látek-substráítů(aniontů).Pokles binární sekrece může být částečně kompenzován zvýšenou renální eliminací v případě metotrexátu, nikoliv u rhodaminu123 (cs)
  • Alterations in transport proteins expression during cholestatsis might produce adaptive changes in pharmacokinetics of drugs-substrates. Decreased biliary secretion may be partly compensated by increased renal elimination (en)
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  • drugs
  • in vivo
  • of impaired liver function
  • pharmacokinetics and pharmacodynamics
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