About: Physiologically based prediction of pharmacokinetics prior to in vivo studies: Focus on hepatic and renal drug elimination     Goto   Sponge   NotDistinct   Permalink

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Description
  • possibilities of combined usage of in vitro methods and computational models in silico for prediction of pharmacokinetics in vivo (en)
  • možnosti kombinovaného použití in vitro metod a počítačových modelů in silico pro predikaci farmakokinetiky léčiv in vivo
Title
  • Physiologically based prediction of pharmacokinetics prior to in vivo studies: Focus on hepatic and renal drug elimination (en)
  • Predikce farmakokinetiky vycházející z fyziologických principů zaměřením na jaterní a ledvinnou eliminaci léčiv
skos:notation
  • 1P05OC061
http://linked.open...avai/cep/aktivita
http://linked.open...kovaStatniPodpora
http://linked.open...ep/celkoveNaklady
http://linked.open...datumDodatniDoRIV
http://linked.open...i/cep/druhSouteze
http://linked.open...ep/duvernostUdaju
http://linked.open.../cep/fazeProjektu
http://linked.open...ai/cep/hlavniObor
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http://linked.open...vai/cep/kategorie
http://linked.open.../cep/klicovaSlova
  • Physiologically based prediction; pharmacokinetics; in vivo; in vitro; in silico; hepatic and renal drug elimination (en)
http://linked.open...ep/partnetrHlavni
http://linked.open...inujicichPrijemcu
http://linked.open...cep/pocetPrijemcu
http://linked.open...ocetSpoluPrijemcu
http://linked.open.../pocetVysledkuRIV
http://linked.open...enychVysledkuVRIV
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http://linked.open.../vavai/cep/soutez
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http://linked.open...ep/ukonceniReseni
http://linked.open...ep/zahajeniReseni
http://linked.open...jektu+dodavatelem
  • The project was focused on in vitro/in silico based prediction of drug pharmacokinetics. Attention was paid to the contribution of hepatic and renal transporters to drug-drug interactions of amiodarone, corticosteroids and macrolide antibiotics. (en)
  • Projekt byl zaměřen na možnosti in vitro/in silico predikce farmakokinetiky léčiv. Pozornost byla soustředěna na hodnocení podílu jaterních a ledvinných transportérů na lékových interakcích amiodaronu, kortikosteroidů a makrolidových antibiotik. (cs)
http://linked.open...tniCyklusProjektu
http://linked.open.../cep/klicoveSlovo
  • in vitro
  • in vivo
  • pharmacokinetics
  • in silico
  • Physiologically based prediction
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