About: Expression of the c-kit protein, EGFR, and HER-2/neu in high grade carcinomas of salivary gland: prognostic or predictive markers?     Goto   Sponge   NotDistinct   Permalink

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Description
  • The aims of project is to study in retrospective histological and immunohistochemical analysis expression of selected biological markers (c-kit, EGFR, and HER-2/neu) in the series of high grade salivary gland carcinomas. It is supposed to find genetic/epigenetic correlations and to associate them with clinical outcomes in patients. Our study is expected to open the way for targeted therapy of some high grade salivary gland carcinomas. (en)
  • Cílem projektu je sledovat imunohistochemicky expresi vybraných onkoproteinů (c-kit, EGFR, a HER-2/neu) v různých typech vysoce maligních salivárních karcinomů a korelovat ji s patomorfologií nádorů a jejich prognózou. Dále budeme vyšetřovat somatické mutace a amplifikace genů kodujících tyto onkoproteiny. Cíle projektu jsou ve shodě s celkovou strategií IGA MZ podporovat projekty zaměřené na včasnou diagnostiku umožňující moderní komplexní terapii zhoubných nádorů.
Title
  • Expression of the c-kit protein, EGFR, and HER-2/neu in high grade carcinomas of salivary gland: prognostic or predictive markers? (en)
  • Exprese c-kit proteinu, EGFR a HER-2/neu v high grade karcinomech slinných žláz: prognostický nebo prediktivní význam?
skos:notation
  • NS9725
http://linked.open...avai/cep/aktivita
http://linked.open...kovaStatniPodpora
http://linked.open...ep/celkoveNaklady
http://linked.open...datumDodatniDoRIV
http://linked.open...i/cep/druhSouteze
http://linked.open...ep/duvernostUdaju
http://linked.open.../cep/fazeProjektu
http://linked.open...ai/cep/hlavniObor
http://linked.open...hodnoceniProjektu
http://linked.open...vai/cep/kategorie
http://linked.open.../cep/klicovaSlova
  • salivary gland; high grade carcinoma; prognosis; targeted therapy; c-kit; HER-2/neu; EGFR; predictive (en)
http://linked.open...ep/partnetrHlavni
http://linked.open...inujicichPrijemcu
http://linked.open...cep/pocetPrijemcu
http://linked.open...ocetSpoluPrijemcu
http://linked.open.../pocetVysledkuRIV
http://linked.open...enychVysledkuVRIV
http://linked.open...lneniVMinulemRoce
http://linked.open.../prideleniPodpory
http://linked.open...iciPoslednihoRoku
http://linked.open...atUdajeProjZameru
http://linked.open.../vavai/cep/soutez
http://linked.open...usZobrazovaneFaze
http://linked.open...ai/cep/typPojektu
http://linked.open...ep/ukonceniReseni
http://linked.open...ep/zahajeniReseni
http://linked.open...jektu+dodavatelem
  • Autoři navrhli novou klasifikaci salivárního duktálního karcinomu na základě jejich imunoprofilu a genotypu a popsali dvě nové nádorové jednotky dosud neznámé v klasifikaci salivárních karcinomů. (cs)
  • New classification of salivary duct carcinoma based on immunoprofile and genotype was proposed. Two priority studies were published with description of new entities hitherto unreconigzed in salivary gland tumor classifications. (en)
http://linked.open...tniCyklusProjektu
http://linked.open.../cep/klicoveSlovo
  • salivary gland
  • EGFR
  • HER-2/neu
  • c-kit
  • high grade carcinoma
  • prognosis
  • targeted therapy
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