About: DNA Condensing Effects and Sequence Selectivity of DNA Binding of Antitumor Noncovalent Polynuclear Platinum Complexes     Goto   Sponge   NotDistinct   Permalink

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  • The noncovalent analogues of antitumor polynuclear platinum complexes represent a structurally discrete class of platinum drugs. Their chemical and biological properties differ significantly from those of most platinum chemotherapeutics, which bind to DNA in a covalent manner by formation of Pt-DNA adducts. In spite of the fact that these noncovalent polynuclear platinum complexes contain no leaving groups, they have been shown to bind to DNA with high affinity.
  • The noncovalent analogues of antitumor polynuclear platinum complexes represent a structurally discrete class of platinum drugs. Their chemical and biological properties differ significantly from those of most platinum chemotherapeutics, which bind to DNA in a covalent manner by formation of Pt-DNA adducts. In spite of the fact that these noncovalent polynuclear platinum complexes contain no leaving groups, they have been shown to bind to DNA with high affinity. (en)
Title
  • DNA Condensing Effects and Sequence Selectivity of DNA Binding of Antitumor Noncovalent Polynuclear Platinum Complexes
  • DNA Condensing Effects and Sequence Selectivity of DNA Binding of Antitumor Noncovalent Polynuclear Platinum Complexes (en)
skos:prefLabel
  • DNA Condensing Effects and Sequence Selectivity of DNA Binding of Antitumor Noncovalent Polynuclear Platinum Complexes
  • DNA Condensing Effects and Sequence Selectivity of DNA Binding of Antitumor Noncovalent Polynuclear Platinum Complexes (en)
skos:notation
  • RIV/68081707:_____/14:00427974!RIV15-GA0-68081707
http://linked.open...avai/riv/aktivita
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  • I, P(GA13-08273S), P(LH13096)
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  • 3
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  • 11992
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  • RIV/68081707:_____/14:00427974
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  • INTERSTRAND CROSS-LINKS; LASER-LIGHT SCATTERING; CALF THYMUS DNA (en)
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  • US - Spojené státy americké
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  • [5869A10A16F6]
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  • Inorganic Chemistry
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  • 53
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  • Brabec, Viktor
  • Farrell, N. P.
  • Malina, Jaroslav
http://linked.open...ain/vavai/riv/wos
  • 000330812700048
issn
  • 0020-1669
number of pages
http://bibframe.org/vocab/doi
  • 10.1021/ic402796k
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