About: Activation of trans geometry in bifunctional mononuclear platinum complexes by a non-bulky methylamine ligand

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In order to shed light on the mechanism that underlies activity of bifunctional mononuclear Pt-II analogs of transplatin we examined in the present work a DNA binding mode of the analog of transplatin, namely trans-[Pt(CH3NH2)(2)Cl-2], in which NH3 groups were replaced only by a small, non-bulky-methylamine-ligand. This choice was made because we were interested to reveal the role of the bulkiness of the amines used to substitute NH3 in transplatin to produce antitumor-active Pt-II drug. The results indicate that trans-[Pt(CH3NH2)(2)Cl-2] forms a markedly higher amount of more distorting intrastrand cross-links than transplatin which forms in DNA preferentially less distorting and persisting monofunctional adducts. Also importantly, the accumulation of trans-[Pt(CH3NH2)(2)Cl-2] in tumor cells was considerably greater than that of transplatin and cisplatin In order to shed light on the mechanism that underlies activity of bifunctional mononuclear Pt-II analogs of transplatin we examined in the present work a DNA binding mode of the analog of transplatin, namely trans-[Pt(CH3NH2)(2)Cl-2], in which NH3 groups were replaced only by a small, non-bulky-methylamine-ligand. This choice was made because we were interested to reveal the role of the bulkiness of the amines used to substitute NH3 in transplatin to produce antitumor-active Pt-II drug. The results indicate that trans-[Pt(CH3NH2)(2)Cl-2] forms a markedly higher amount of more distorting intrastrand cross-links than transplatin which forms in DNA preferentially less distorting and persisting monofunctional adducts. Also importantly, the accumulation of trans-[Pt(CH3NH2)(2)Cl-2] in tumor cells was considerably greater than that of transplatin and cisplatin (en)
Title	Activation of trans geometry in bifunctional mononuclear platinum complexes by a non-bulky methylamine ligand Activation of trans geometry in bifunctional mononuclear platinum complexes by a non-bulky methylamine ligand (en)
skos:prefLabel	Activation of trans geometry in bifunctional mononuclear platinum complexes by a non-bulky methylamine ligand Activation of trans geometry in bifunctional mononuclear platinum complexes by a non-bulky methylamine ligand (en)
skos:notation	RIV/68081707:_____/13:00399490!RIV14-GA0-68081707
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(EE2.3.20.0057), P(GA13-08273S), P(GAP301/10/0598), S, Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	SEP2013
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Brabec, Viktor Štěpánková, Jana Kašpárková, Jana Nováková, Olga Novohradský, Vojtěch
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	59392
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/13:00399490
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HETEROCYCLIC AMINE LIGAND; INTERSTRAND CROSS-LINKS; DNA-BINDING MODE (en)
http://linked.open.../riv/klicoveSlovo	DNA-BINDING MODE HETEROCYCLIC AMINE LIGAND INTERSTRAND CROSS-LINKS
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[36ABD2572721]
http://linked.open...i/riv/nazevZdroje	Journal of Inorganic Biochemistry
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Biophysical analysis of DNA condensation. Effect of new organometallic compounds of biological significance. Progress and internationalization of biophysical research at Faculty of Science, Palacky University in Olomouc Metallodrugs based on osmium, platinum and ruthenium complexes. From mechanistic studies to novel, more efficient chemotherapy of cancer
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	126
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Kašpárková, Jana Nováková, Olga Štěpánková, Jana Novohradský, Vojtěch Gibson, D. Frýbortová, M.
http://linked.open...ain/vavai/riv/wos	000322942400007
http://linked.open...n/vavai/riv/zamer	Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0162-0134
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.jinorgbio.2013.05.009

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