About: Redox state of p63 and p73 core domains regulates sequence-specific DNA binding

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About: Redox state of p63 and p73 core domains regulates sequence-specific DNA binding Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cysteine oxidation and covalent modification of redox sensitive transcription factors including p53 are known, among others, as important events in cell response to oxidative stress. All p53 family proteins p53, p63 and p73 act as stress-responsive transcription factors. Oxidation of p53 central DNA binding domain destroys its structure and abolishes its sequence-specific binding by affecting zinc ion coordination at the protein-DNA interface. Proteins p63 and p73 can bind the same response elements as p53 but exhibit distinct functions. Moreover, all three proteins contain highly conserved cysteines in central DNA binding domain suitable for possible redox modulation. Cysteine oxidation and covalent modification of redox sensitive transcription factors including p53 are known, among others, as important events in cell response to oxidative stress. All p53 family proteins p53, p63 and p73 act as stress-responsive transcription factors. Oxidation of p53 central DNA binding domain destroys its structure and abolishes its sequence-specific binding by affecting zinc ion coordination at the protein-DNA interface. Proteins p63 and p73 can bind the same response elements as p53 but exhibit distinct functions. Moreover, all three proteins contain highly conserved cysteines in central DNA binding domain suitable for possible redox modulation. (en)
Title	Redox state of p63 and p73 core domains regulates sequence-specific DNA binding Redox state of p63 and p73 core domains regulates sequence-specific DNA binding (en)
skos:prefLabel	Redox state of p63 and p73 core domains regulates sequence-specific DNA binding Redox state of p63 and p73 core domains regulates sequence-specific DNA binding (en)
skos:notation	RIV/68081707:_____/13:00392682!RIV14-GA0-68081707
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP301/10/2370), P(GAP301/11/2076)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Tichý, Vlastimil Adámik, Matěj Navrátilová, Lucie Fojta, Miroslav Brázdová, Marie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	101830
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/13:00392682
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	TUMOR-SUPPRESSOR P53; RESPONSE ELEMENTS; SUPERCOILED DNA (en)
http://linked.open.../riv/klicoveSlovo	RESPONSE ELEMENTS TUMOR-SUPPRESSOR P53 SUPERCOILED DNA
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[E8DFB959BD3D]
http://linked.open...i/riv/nazevZdroje	Biochemical and Biophysical Research Communications
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	DNA binding, stress-induced expression and transactivation activity of p73 protein isoforms The role of p53 DNA structure-selective binding in brain cancer
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	433
http://linked.open...iv/tvurceVysledku	Brázdová, Marie Fojta, Miroslav Navrátilová, Lucie Adámik, Matěj Tichý, Vlastimil
http://linked.open...ain/vavai/riv/wos	000318259100016
issn	0006-291X
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.bbrc.2013.02.097

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