About: Mechanistic insights into antitumor effects of new dinuclear cis PtII complexes containing aromatic linkers

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About: Mechanistic insights into antitumor effects of new dinuclear cis PtII complexes containing aromatic linkers Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The primary objective was to understand more deeply the molecular mechanism underlying different antitumor effects of dinuclear Pt-II complexes containing aromatic linkers of different length, ([cisPt( NH3)(2)Cl](2)(4,4'-methylenedianiline)}(2+) (1) and {[cis-Pt(NH3)(2)Cl](2)(alpha,alpha'-diamino-p-xylene)}(2+) (2). These complexes belong to a new generation of promising polynuclear platinum drugs resistant to decomposition by sulfur nucleophiles which hampers clinical use of bifunctional polynuclear trans Pt-II complexes hitherto tested. The primary objective was to understand more deeply the molecular mechanism underlying different antitumor effects of dinuclear Pt-II complexes containing aromatic linkers of different length, ([cisPt( NH3)(2)Cl](2)(4,4'-methylenedianiline)}(2+) (1) and {[cis-Pt(NH3)(2)Cl](2)(alpha,alpha'-diamino-p-xylene)}(2+) (2). These complexes belong to a new generation of promising polynuclear platinum drugs resistant to decomposition by sulfur nucleophiles which hampers clinical use of bifunctional polynuclear trans Pt-II complexes hitherto tested. (en)
Title	Mechanistic insights into antitumor effects of new dinuclear cis PtII complexes containing aromatic linkers Mechanistic insights into antitumor effects of new dinuclear cis PtII complexes containing aromatic linkers (en)
skos:prefLabel	Mechanistic insights into antitumor effects of new dinuclear cis PtII complexes containing aromatic linkers Mechanistic insights into antitumor effects of new dinuclear cis PtII complexes containing aromatic linkers (en)
skos:notation	RIV/68081707:_____/10:00373395!RIV12-AV0-68081707
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP301/10/0598), P(GD301/09/H004), P(IAA400040803), P(KAN200200651), P(LC06030), P(ME08017), P(ME10066), P(OC08003), P(OC09018), Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Kostrhunová, Hana Brabec, Viktor Kašpárková, Jana Nováková, Olga Zerzánková, Lenka Vojtíšková, Marie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	270194
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/10:00373395
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DNA; platinum; cancer (en)
http://linked.open.../riv/klicoveSlovo	DNA cancer platinum
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[AE6CDEFAEE41]
http://linked.open...i/riv/nazevZdroje	Biochemical Pharmacology
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Platinum Metal Complexes as DNA-Protein Cross-Linking Agents Structure, recognition, and processing of DNA damage by metal-based compounds of biological significance Molecular and structural biology of selected antitumor drugs. From mechanistic studies to chemotherapy of tumors Nanoparticulate and supramolecular systems for targeted drug delivery Biomolecular centre Mechanism of antitumor activity of metallodrugs. DNA replication and repair of DNA damage Metallodrugs based on osmium, platinum and ruthenium complexes. From mechanistic studies to novel, more efficient chemotherapy of cancer Mechanistic studies related to targeted cancer chemotherapy with light-activated platinum and ruthenium antitumor agents Transition metal-based anticancer compounds. From mechanistic studies to innovatory cancer chemotherapy
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	80
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Kostrhunová, Hana Kašpárková, Jana Zerzánková, Lenka Nováková, Olga Vojtíšková, Marie Guo, Z. Suchánková, T. Lin, M.
http://linked.open...ain/vavai/riv/wos	000278712100007
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0006-2952
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.bcp.2010.04.013

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