About: Studies on cellular accumulation of satraplatin and its major metabolite JM118 and their interactions with glutathione     Goto   Sponge   NotDistinct   Permalink

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Description
  • The organic cation transporters play a more important role in the mechanism of cytotoxicity of JM118 than in the cytotoxicity of cisplatin. Satraplatin is a poor substrate of these transporters. Satraplatin reacts with glutathione with the rate markedly lower than JM118 and cisplatin. Satraplatin can be activated by glutathione allowing it to react with DNA.
  • The organic cation transporters play a more important role in the mechanism of cytotoxicity of JM118 than in the cytotoxicity of cisplatin. Satraplatin is a poor substrate of these transporters. Satraplatin reacts with glutathione with the rate markedly lower than JM118 and cisplatin. Satraplatin can be activated by glutathione allowing it to react with DNA. (en)
Title
  • Studies on cellular accumulation of satraplatin and its major metabolite JM118 and their interactions with glutathione
  • Studies on cellular accumulation of satraplatin and its major metabolite JM118 and their interactions with glutathione (en)
skos:prefLabel
  • Studies on cellular accumulation of satraplatin and its major metabolite JM118 and their interactions with glutathione
  • Studies on cellular accumulation of satraplatin and its major metabolite JM118 and their interactions with glutathione (en)
skos:notation
  • RIV/68081707:_____/10:00353777!RIV11-MSM-68081707
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GAP301/10/0598), P(IAA400040803), P(ME08017), P(ME10066), P(OC08003), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika
  • 6
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 290639
http://linked.open...ai/riv/idVysledku
  • RIV/68081707:_____/10:00353777
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • JM118; cellular accumulation; glutathione (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [D70AE45FC365]
http://linked.open...i/riv/nazevZdroje
  • MOLECULAR PHARMACEUTICS
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 7
http://linked.open...iv/tvurceVysledku
  • Brabec, Viktor
  • Kostrhunová, Hana
  • Kašpárková, Jana
  • Gibson, D.
http://linked.open...ain/vavai/riv/wos
  • 000284865900020
http://linked.open...n/vavai/riv/zamer
issn
  • 1543-8384
number of pages
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