About: Studies of the mechanism of action of platinum(II) complexes with potent cytotoxicity in human cancer cells

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About: Studies of the mechanism of action of platinum(II) complexes with potent cytotoxicity in human cancer cells Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We have examined activity of 12 Pt(II)-based DNA intercalators of the type [Pt(IL)(AL)]2+, where IL is an intercalating ligand (1,10-phenanthroline or a methylated derivative) and AL is an ancillary ligand (diaminocyclohexane, diphenylethylenediamine or 1,2-bis(4-fluorophenyl)-1,2-ethylenediamine) against a panel of human cancer cell lines and further in vitro testing was conducted to provide information about the mechanism of action. We have examined activity of 12 Pt(II)-based DNA intercalators of the type [Pt(IL)(AL)]2+, where IL is an intercalating ligand (1,10-phenanthroline or a methylated derivative) and AL is an ancillary ligand (diaminocyclohexane, diphenylethylenediamine or 1,2-bis(4-fluorophenyl)-1,2-ethylenediamine) against a panel of human cancer cell lines and further in vitro testing was conducted to provide information about the mechanism of action. (en)
Title	Studies of the mechanism of action of platinum(II) complexes with potent cytotoxicity in human cancer cells Studies of the mechanism of action of platinum(II) complexes with potent cytotoxicity in human cancer cells (en)
skos:prefLabel	Studies of the mechanism of action of platinum(II) complexes with potent cytotoxicity in human cancer cells Studies of the mechanism of action of platinum(II) complexes with potent cytotoxicity in human cancer cells (en)
skos:notation	RIV/68081707:_____/09:00329490!RIV10-MSM-68081707
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS500040581), P(IAA400040803), P(KAN200200651), P(LC06030), P(ME08017), P(OC08003), P(OC09018), Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	17
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Brabec, Viktor Kašpárková, Jana Malina, Jaroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	344350
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/09:00329490
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	platinum; metallointercalator; cytotoxicity (en)
http://linked.open.../riv/klicoveSlovo	cytotoxicity platinum metallointercalator
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[025340A3A1DF]
http://linked.open...i/riv/nazevZdroje	Journal of Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	AQ
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	13 (xsd:int)
http://linked.open...vavai/riv/projekt	Metallodrugs, design and mechansim of action Platinum Metal Complexes as DNA-Protein Cross-Linking Agents Structure, recognition, and processing of DNA damage by metal-based compounds of biological significance Nanoparticulate and supramolecular systems for targeted drug delivery Biomolecular centre Mechanism of antitumor activity of metallodrugs. DNA replication and repair of DNA damage Mechanistic studies related to targeted cancer chemotherapy with light-activated platinum and ruthenium antitumor agents
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	52
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Kašpárková, Jana Malina, Jaroslav Bednarski, P. J. Grüner, R. Aldrich-Wright, J. R. Boag, L. R. Buczkowska, M. Fisher, D. M. Krause-Heuer, A. M. Kühne, S. Le Pevelen, D. D. Wheate, N. J.
http://linked.open...ain/vavai/riv/wos	000269655500020
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0022-2623
number of pages	11 (xsd:int)

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