About: Cytotoxicity, mutagenicity, cellular uptake, DNA and glutathione interactions of lipophilic trans-platinum complexes tethered to 1-adamantylamine

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About: Cytotoxicity, mutagenicity, cellular uptake, DNA and glutathione interactions of lipophilic trans-platinum complexes tethered to 1-adamantylamine Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cytotoxicity and mutagenicity of trans,trans,trans-[PtCl2(CH3COO)2(NH3)(1-adamantylamine)] [trans-adamplatin(IV)] and its reduced analog trans-[PtCl2(NH3)(1-adamantylamine)] [trans-adamplatin(II)] were examined. A notable feature of the growth inhibition studies was the remarkable circumvention of both acquired and intrinsic cisplatin resistance by the two lipophilic trans-compounds. The results also demonstrate that trans-adamplatin(II) exhibits DNA binding mode markedly different from that of ineffective transplatin. Cytotoxicity and mutagenicity of trans,trans,trans-[PtCl2(CH3COO)2(NH3)(1-adamantylamine)] [trans-adamplatin(IV)] and its reduced analog trans-[PtCl2(NH3)(1-adamantylamine)] [trans-adamplatin(II)] were examined. A notable feature of the growth inhibition studies was the remarkable circumvention of both acquired and intrinsic cisplatin resistance by the two lipophilic trans-compounds. The results also demonstrate that trans-adamplatin(II) exhibits DNA binding mode markedly different from that of ineffective transplatin. (en) Byly studovány cytotoxicita a mutagenicita komplexů of trans,trans,trans-[PtCl2(CH3COO)2(NH3)(1-adamantylamine)] [trans-adamplatin(IV)] and its reduced analog trans-[PtCl2(NH3)(1-adamantylamine)] [trans-adamplatin(II)]. Pozoruhodným rysem studií zaměřených na inhibici růstu buněk bylo pozoruhodné obejití jak zíkané tak vlastní rezistence k cisplatině. Výsledky také ukazují, že komplex trans-adamplatin(II) vykazuje vazebné vlastnosti k DNA výrazně odlišné ve srovnání s cisplatinou. (cs)
Title	Cytotoxicity, mutagenicity, cellular uptake, DNA and glutathione interactions of lipophilic trans-platinum complexes tethered to 1-adamantylamine Cytotoxicity, mutagenicity, cellular uptake, DNA and glutathione interactions of lipophilic trans-platinum complexes tethered to 1-adamantylamine (en) Cytotoxicita, mutagenicita, buněčný příjem, interakce s DNA a glutathionem lipofilních komplexů transplatiny připojených k 1-adamantylaminu (cs)
skos:prefLabel	Cytotoxicity, mutagenicity, cellular uptake, DNA and glutathione interactions of lipophilic trans-platinum complexes tethered to 1-adamantylamine Cytotoxicity, mutagenicity, cellular uptake, DNA and glutathione interactions of lipophilic trans-platinum complexes tethered to 1-adamantylamine (en) Cytotoxicita, mutagenicita, buněčný příjem, interakce s DNA a glutathionem lipofilních komplexů transplatiny připojených k 1-adamantylaminu (cs)
skos:notation	RIV/68081707:_____/08:00306732!RIV08-AV0-68081707
http://linked.open.../vavai/riv/strany	1077;1089
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS500040581), P(GA305/05/2030), P(KAN200200651), P(LC06030), P(NR8562), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	5-6
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Brabec, Viktor Kašpárková, Jana Kisová-Halámiková, Anna Heringová, Pavla
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	361900
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/08:00306732
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DNA; platinum; cancer (en)
http://linked.open.../riv/klicoveSlovo	DNA cancer platinum
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[37EF499EF239]
http://linked.open...i/riv/nazevZdroje	Journal of Inorganic Biochemistry
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Metallodrugs, design and mechansim of action New approaches to cancer chemotherapy by metal-based drugs Nanoparticulate and supramolecular systems for targeted drug delivery Biomolecular centre Inhibition of telomerase by transition metal complexes. A new concept of antitumor drug design
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	102
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Kašpárková, Jana Natile, G. Gibson, D. Halámiková, Anna Heringová, Pavla Intini, F. P. Nemirovski, A.
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0162-0134
number of pages	13 (xsd:int)

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