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rdf:type
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Description
| - Nuclear arrangement, in correlation with transcriptional activity, of 0ct4 and the c-myc gene was investigated in human embryonic stem cells (hESC) undergoing differentiation. Additionally, nuclear distribution of all subtypes of HP1 protein was studied in this experimental system. The structures responsible for hESC pluripotency were characterized by more de-condensed nuclear arrangement, while more conserved nuclear topography was found for structures responsible for cell cycle regulation and/or differentiation, such as the c-myc gene.
- Nuclear arrangement, in correlation with transcriptional activity, of 0ct4 and the c-myc gene was investigated in human embryonic stem cells (hESC) undergoing differentiation. Additionally, nuclear distribution of all subtypes of HP1 protein was studied in this experimental system. The structures responsible for hESC pluripotency were characterized by more de-condensed nuclear arrangement, while more conserved nuclear topography was found for structures responsible for cell cycle regulation and/or differentiation, such as the c-myc gene. (en)
- Korelace mezi jaderným uspořádáním a transkripční aktivitou Oct4 a c-myc genů byly studovány u lidských embryonálních kmenových buněk (hESC) stimulovaných k diferenciaci. Jaderná distribuce všech variant HP1 proteinu byla navíc testována v tomto experimentálním systému. Struktury zodpovědné za hESC pluripotentnost byly charakteristické větší mírou de-kondenzace, než struktury, takové jako je c-myc gen, zodpovědné za regulaci buněčného cyklu nebo indukci diferenciace. (cs)
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Title
| - Differentiation of human embryonic stem cells induces condensation of chromosome territories and formation of heterochromatin protein 1 foci
- Differentiation of human embryonic stem cells induces condensation of chromosome territories and formation of heterochromatin protein 1 foci (en)
- Diferenciace lidských embryonálních kmenových buněk indukuje kondenzaci chromosomálních teritorií a tvorbu ohnisek HP+ proteinu (cs)
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skos:prefLabel
| - Differentiation of human embryonic stem cells induces condensation of chromosome territories and formation of heterochromatin protein 1 foci
- Differentiation of human embryonic stem cells induces condensation of chromosome territories and formation of heterochromatin protein 1 foci (en)
- Diferenciace lidských embryonálních kmenových buněk indukuje kondenzaci chromosomálních teritorií a tvorbu ohnisek HP+ proteinu (cs)
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skos:notation
| - RIV/68081707:_____/08:00305724!RIV08-AV0-68081707
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(1P05OC084), P(1QS500040508), P(GA204/06/0978), P(IAA5004306), P(LC535), Z(AV0Z50040507), Z(AV0Z50040702)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/08:00305724
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - differentiation; human embryonic stem cells; chromatin structure (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Bártová, Eva
- Kozubek, Stanislav
- Kroupová, Jana
- Harničarová, Andrea
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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