About: Bifunctional amine-tethered ruthenium(II) arene complexes form monofunctional adducts on DNA

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The tethered RuII half-sandwich complexes [éta6:éta1-C6H5(CH2)nNH2)RuCl2] n=2 or 3 have been synthesized as potential bifunctional anticancer complexes, and their X-ray crystal structures have been determined. These complexes readily ruthenate calf thymus DNA so that only monofunctional DNA adducts are formel. These findings may explain why these complexes exhibit low cytotoxicities toward A2780 human ovarian cancer cells. The tethered RuII half-sandwich complexes [éta6:éta1-C6H5(CH2)nNH2)RuCl2] n=2 or 3 have been synthesized as potential bifunctional anticancer complexes, and their X-ray crystal structures have been determined. These complexes readily ruthenate calf thymus DNA so that only monofunctional DNA adducts are formel. These findings may explain why these complexes exhibit low cytotoxicities toward A2780 human ovarian cancer cells. (en) Arenové komplexy RuII [éta6:éta1-C6H5(CH2)nNH2)RuCl2] n=2 nebo 3 byly syntetizovány jako potenciální protinádorová léčiva. Byly také určeny jejich krystalografické struktury. Komplexy se váží na DNA, a to tak, že vytváří monofunkční adukty. Tyto výsledky mohou vysvětlit proč tyto komplexy vykazují pouze slabé cytotoxické efekty lidských ovariálních nádorových buňkách A2780. (cs)
Title	Bifunctional amine-tethered ruthenium(II) arene complexes form monofunctional adducts on DNA Bifunctional amine-tethered ruthenium(II) arene complexes form monofunctional adducts on DNA (en) Bifunkční arenové komplexy Ru(II) s navázaným aminem vytvářejí na DNA monofunkční adukty (cs)
skos:prefLabel	Bifunctional amine-tethered ruthenium(II) arene complexes form monofunctional adducts on DNA Bifunctional amine-tethered ruthenium(II) arene complexes form monofunctional adducts on DNA (en) Bifunkční arenové komplexy Ru(II) s navázaným aminem vytvářejí na DNA monofunkční adukty (cs)
skos:notation	RIV/68081707:_____/07:00091784!RIV08-AV0-68081707
http://linked.open.../vavai/riv/strany	8950;8962
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS500040581), P(GA203/06/1239), P(GA305/05/2030), P(KAN200200651), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	21
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Brabec, Viktor Nováková, Olga
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	411720
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/07:00091784
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DNA; ruthenium; cancer (en)
http://linked.open.../riv/klicoveSlovo	DNA cancer ruthenium
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[D0E0ACE097BB]
http://linked.open...i/riv/nazevZdroje	Inorganic Chemistry
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Metallodrugs, design and mechansim of action New approaches to cancer chemotherapy by metal-based drugs Nanoparticulate and supramolecular systems for targeted drug delivery Tolerance and bypass of DNA damage by metal-based anticancer drugs
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	46
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Habtemariam, A. Sadler, P. J. Nováková, Olga Parsons, S. Moggach, S. A. Fabbiani, F. P. A. Melchart, M.
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0020-1669
number of pages	13 (xsd:int)

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