About: Recogntiton of DNA modified by trans-[PtCl2NHš(4-hydroxymethylpyridine)] by tumor suppressor protein p53 and character of DNA adducts of this cytotoxic complex

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About: Recogntiton of DNA modified by trans-[PtCl2NHš(4-hydroxymethylpyridine)] by tumor suppressor protein p53 and character of DNA adducts of this cytotoxic complex Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Nahrazení skupiny NH3 v molekule transplatiny 4 hydroxymethylpyridinem ovlivňuje charakter aduktů vytvořených na DNA. Adukty vytvořené na DNA komplexem trans-[PtCl2NH3(4-hydroxymethylpyridin)](trans-PtHMP) také snižují afinitu proteinu p53 k jeho konsensuální sekvenci v DNA. Bylo navrženo, že tyto rozdílné efekty mohou přispět k rozdílné protinádorové účinnosti transplatiny a trans-PtHMP. (cs) The replacement of the NH3 group in transplatin by the 4 hydroxymethylpyridine ligand affects the character of DNA adducts of parent transplatin. DNA adducts of trans-[PtCl2NH3(4-hydroxymethylpyridine)](trans-PtHMP) also reduce the affinity of the p53 protein to its consensus DNA sequence. It has been suggested that these different effects may contribute to different antitumor effects of transplatin and trans-PtHMP. The replacement of the NH3 group in transplatin by the 4 hydroxymethylpyridine ligand affects the character of DNA adducts of parent transplatin. DNA adducts of trans-[PtCl2NH3(4-hydroxymethylpyridine)](trans-PtHMP) also reduce the affinity of the p53 protein to its consensus DNA sequence. It has been suggested that these different effects may contribute to different antitumor effects of transplatin and trans-PtHMP. (en)
Title	Recogntiton of DNA modified by trans-[PtCl2NHš(4-hydroxymethylpyridine)] by tumor suppressor protein p53 and character of DNA adducts of this cytotoxic complex Rozlišení DNA modifikované komplexem trans-[PtCl2NH3(4-hydroxymethylpyridine)] tumorovým supresorovým proteinem p53 a charakter aduktů vytvořených tímto komplexem na DNA (cs) Recogntiton of DNA modified by trans-[PtCl2NHš(4-hydroxymethylpyridine)] by tumor suppressor protein p53 and character of DNA adducts of this cytotoxic complex (en)
skos:prefLabel	Recogntiton of DNA modified by trans-[PtCl2NHš(4-hydroxymethylpyridine)] by tumor suppressor protein p53 and character of DNA adducts of this cytotoxic complex Rozlišení DNA modifikované komplexem trans-[PtCl2NH3(4-hydroxymethylpyridine)] tumorovým supresorovým proteinem p53 a charakter aduktů vytvořených tímto komplexem na DNA (cs) Recogntiton of DNA modified by trans-[PtCl2NHš(4-hydroxymethylpyridine)] by tumor suppressor protein p53 and character of DNA adducts of this cytotoxic complex (en)
skos:notation	RIV/68081707:_____/06:00048159!RIV07-GA0-68081707
http://linked.open.../vavai/riv/strany	301;314
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA305/05/2030), P(GD204/03/H016), P(NR8562)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Brabec, Viktor Kašpárková, Jana Nováková, Olga Stehlíková, Kristýna
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	496723
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/06:00048159
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cancer; platinum; DNA (en)
http://linked.open.../riv/klicoveSlovo	DNA cancer platinum
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[6095823DDB81]
http://linked.open...i/riv/nazevZdroje	FEBS Journal
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	New approaches to cancer chemotherapy by metal-based drugs Structural biophysics of macromolecules Inhibition of telomerase by transition metal complexes. A new concept of antitumor drug design
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	273
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Kašpárková, Jana Nováková, Olga Stehlíková, Kristýna Martínez, Alberto Moreno, Virtudes
issn	1742-464X
number of pages	14 (xsd:int)

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