About: Thermodynamic properties of damaged DNA and its recognition by xeroderma pigmentosum group A protein and replication protein A

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The effects of the lesions induced by single, site-specific 1,2-GG or 1,3-GTG intrastrand adducts of cis-diamminedichloroplatinum(II) formed in oligodeoxyribonucleotide duplexes on energetics of DNA were examined by means of differential scanning calorimetry. The results confirm that rigid DNA bending is the specific determinant responsible for high-affinity interactions of XPA with damaged DNA. In addition, the results also confirm that RPA preferentially binds to DNA distorted so that hydrogen bonds between complementary bases are interrupted. The effects of the lesions induced by single, site-specific 1,2-GG or 1,3-GTG intrastrand adducts of cis-diamminedichloroplatinum(II) formed in oligodeoxyribonucleotide duplexes on energetics of DNA were examined by means of differential scanning calorimetry. The results confirm that rigid DNA bending is the specific determinant responsible for high-affinity interactions of XPA with damaged DNA. In addition, the results also confirm that RPA preferentially binds to DNA distorted so that hydrogen bonds between complementary bases are interrupted. (en) Efekty lézí vyvolaných v oligodeoxyribonukleotidových duplexech 1,2-GG nebo 1,3-GTG vnitrořetězcovými můstky cis-diammindichloroplatnatým komplexem na energetiku DNA byly zkoumány pomocí diferenční skenovací kalorimetrie. Výsledky potvrzují, že rigidní ohyb DNA je specifickou determinantou zodpovědnou za vysokou afinitu proteinu XPA k poškozené DNA. Kromě toho výsledky také potvrzují, že RPA se preferenčně váže k DNA poškozené do té míry, že vodíkové vazby mezi komplementárními bázemi jsou přerušeny. (cs)
Title	Thermodynamic properties of damaged DNA and its recognition by xeroderma pigmentosum group A protein and replication protein A Thermodynamic properties of damaged DNA and its recognition by xeroderma pigmentosum group A protein and replication protein A (en) Termodynamické vlastnosti poškozené DNA a její rozlišení proteiny xeroderma pigmentosum skupina A a replikačním proteinem A (cs)
skos:prefLabel	Thermodynamic properties of damaged DNA and its recognition by xeroderma pigmentosum group A protein and replication protein A Thermodynamic properties of damaged DNA and its recognition by xeroderma pigmentosum group A protein and replication protein A (en) Termodynamické vlastnosti poškozené DNA a její rozlišení proteiny xeroderma pigmentosum skupina A a replikačním proteinem A (cs)
skos:notation	RIV/68081707:_____/06:00048149!RIV07-AV0-68081707
http://linked.open.../vavai/riv/strany	1;10
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/05/2030), P(GD204/03/H016), P(KJB400040601), P(NR8562), Z(AV0Z50040507)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Brabec, Viktor Kašpárková, Jana Malina, Jaroslav Stehlíková, Kristýna Vojtíšková, Marie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	503792
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/06:00048149
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	differential scanning calorimetry; xeroderma pigmentosum group A protein; replication protein A (en)
http://linked.open.../riv/klicoveSlovo	differential scanning calorimetry replication protein A xeroderma pigmentosum group A protein
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[0CFFA0FA37B5]
http://linked.open...i/riv/nazevZdroje	Archives of Biochemistry and Biophysics
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Recognition of DNA modified by antitumor platinum and ruthenium complexes by zinc-finger proteins and topoisomerases New approaches to cancer chemotherapy by metal-based drugs Structural biophysics of macromolecules Inhibition of telomerase by transition metal complexes. A new concept of antitumor drug design
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	446
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Kašpárková, Jana Malina, Jaroslav Vojtíšková, Marie Stehlíková, Kristýna
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems
issn	0003-9861
number of pages	10 (xsd:int)

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