| Attributes | Values |
|---|
| rdf:type
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| Description
| - v Antigenní markery heterochromatinických proteinů, které jsou běžně přítomny v jádrech lidských progenitorových buněk CD34+, diferencovaných lymfocytů a monocytů, nejsou přítomny v jádrech neutrofilních a ve značném rozsahu rovněž eosinofilních granulocytů. V granulocytech pacientů s akutní CML a AML byly detekovány všechny isoformy HP1 a silná metylace histonu H3K9. V chronických formách CML nebyla nalezená žádná silná korelace mezi hladinou metylace histonu H3, progresí choroby a způsobem léčby. Naprogramování leukemických buněk HL-60 na terminální diferenciaci pomocí retinové kyseliny nemělo za následek eliminaci metylace histonu H3 a absenci isoforem HP1 proteinu v diferencovaných granulocytech. Naše výsledky jsou první, které ukazují, že metylace histonu H3K9 může být dramaticky změněna v průběhu normální buněčné diferenciace. (cs)
- Common heterochromatin antigenic protein markers while present in human blood progenitor CD34+ cells, differentiated lymphocytes and monocytes are absent in neutrophile granulocytes and, to large extent, in eosinophiles. In acute CML and AML, strong methylation of H3K9 and all isoformes of HP1 are detected. In chronic forms of CML, no strong correlations among the level of histone methylation, disease progression and modality of treatment were observed. Reprogramming of leukemia HL60 cells to terminal differentiation by retinoic acid does not eliminate histone H3K9 methylation and the presence of HP1 isoformes from differentiated granulocytes. Our study shows for the firs time that histone H3 methylation may be dramatically changed during normal cell differentiation.
- Common heterochromatin antigenic protein markers while present in human blood progenitor CD34+ cells, differentiated lymphocytes and monocytes are absent in neutrophile granulocytes and, to large extent, in eosinophiles. In acute CML and AML, strong methylation of H3K9 and all isoformes of HP1 are detected. In chronic forms of CML, no strong correlations among the level of histone methylation, disease progression and modality of treatment were observed. Reprogramming of leukemia HL60 cells to terminal differentiation by retinoic acid does not eliminate histone H3K9 methylation and the presence of HP1 isoformes from differentiated granulocytes. Our study shows for the firs time that histone H3 methylation may be dramatically changed during normal cell differentiation. (en)
|
| Title
| - Methylation of histone H3K9 in human blood cells and in granulocytes of patients with myeloid leukemia
- Methylation of histone H3K9 in human blood cells and in granulocytes of patients with myeloid leukemia (en)
- Methylace histonu H3K9 v lidských krevních buňkách a v granulocytech pacientů s myeloidní leukemií (cs)
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| skos:prefLabel
| - Methylation of histone H3K9 in human blood cells and in granulocytes of patients with myeloid leukemia
- Methylation of histone H3K9 in human blood cells and in granulocytes of patients with myeloid leukemia (en)
- Methylace histonu H3K9 v lidských krevních buňkách a v granulocytech pacientů s myeloidní leukemií (cs)
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| skos:notation
| - RIV/68081707:_____/04:00108436!RIV/2005/AV0/A17005/N
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| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(GA202/02/0804), P(IAA1065203), P(KSK5052113), P(ME 565), P(NC6987), Z(AV0Z5004920)
|
| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/04:00108436
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - human granulocytes; chromatin condensation; retinoic acid (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...v/mistoKonaniAkce
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| http://linked.open...i/riv/mistoVydani
| |
| http://linked.open...i/riv/nazevZdroje
| - Biophysics of the Genome: Proceedings of the Workshop Held at Brno
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...iv/tvurceVysledku
| - Kozubek, Stanislav
- Lukášová, Emilie
- Ondřej, Vladan
- Falk, Martin
- Kozubek, M.
- Kroupová, I.
- Grigoryev, S.
- Kořistek, Z.
|
| http://linked.open...vavai/riv/typAkce
| |
| http://linked.open.../riv/zahajeniAkce
| |
| http://linked.open...n/vavai/riv/zamer
| |
| number of pages
| |
| http://purl.org/ne...btex#hasPublisher
| - Masarykova univerzita v Brně
|
| https://schema.org/isbn
| |
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