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Description
| - The effects of several synthetic adenosine receptor agonists on the growth characteristics of murine G:5:113 fibrosarcoma cells in vitro were evaluated. Cell number and viability, as well as proportions of cells in individual cell cycle phases, were determined after 48 h cultivation of the cells in the presence of concentrations of adenosine receptor agonists ranging between 0.01 and 500 muM. Effects of the non-selective adenosine receptor agonist NECA, as well as of agonists selective for A(1) (CPA), A(2A) (CGS 21680), and A(3) receptors (IB-MECA) were evaluated. A slight increase in cell number was observed at a narrow range of concentrations between 30-50 muM of NECA, which was reproduced by CPA, a selective A, receptor agonist, in concentrations ranging from 20-50 muM. The most important finding was that of significant inhibitory effects of adenosine receptor agonists on cell number in concentrations above 50 muM.
- The effects of several synthetic adenosine receptor agonists on the growth characteristics of murine G:5:113 fibrosarcoma cells in vitro were evaluated. Cell number and viability, as well as proportions of cells in individual cell cycle phases, were determined after 48 h cultivation of the cells in the presence of concentrations of adenosine receptor agonists ranging between 0.01 and 500 muM. Effects of the non-selective adenosine receptor agonist NECA, as well as of agonists selective for A(1) (CPA), A(2A) (CGS 21680), and A(3) receptors (IB-MECA) were evaluated. A slight increase in cell number was observed at a narrow range of concentrations between 30-50 muM of NECA, which was reproduced by CPA, a selective A, receptor agonist, in concentrations ranging from 20-50 muM. The most important finding was that of significant inhibitory effects of adenosine receptor agonists on cell number in concentrations above 50 muM. (en)
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Title
| - Effects of synthetic adenosine receptor agonists on growth characteristics of G:5:113 fibrosarcoma cells in vitro.
- Effects of synthetic adenosine receptor agonists on growth characteristics of G:5:113 fibrosarcoma cells in vitro. (en)
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skos:prefLabel
| - Effects of synthetic adenosine receptor agonists on growth characteristics of G:5:113 fibrosarcoma cells in vitro.
- Effects of synthetic adenosine receptor agonists on growth characteristics of G:5:113 fibrosarcoma cells in vitro. (en)
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skos:notation
| - RIV/68081707:_____/03:17033128!RIV/2004/AV0/A17004/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA305/02/0423), P(IBS5004009), P(KSK5011112), Z(AV0Z5004920)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/03:17033128
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - adenosine receptor agonists; fibrosarcoma; tumor cell proliferation (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Drug Development Research
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...ocetUcastnikuAkce
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http://linked.open...nichUcastnikuAkce
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Hofer, Michal
- Hoferová, Zuzana
- Pospíšil, Milan
- Znojil, V.
- Minksová, Kateřina
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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