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| rdf:type
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| Description
| - Exprese endothelin-konvertujícího enzymu během vývoje podporuje spolu s jejími změnami podmíněnými hemodynamikou a následky farmakologické blokády hypotézu, že endotelinová signalizace hraje významnou úlohu při normální specifikaci převodního systému. (cs)
- The spatiotemporal distribution of the endothelin-converting enzyme (ECE) protein in the embryonic chick heart and the association of this polypeptide with the developing cardiac conduction system is described here for the first time. Further, we show how cardiac hemodynamic load directly affects ECE level and distribution. Endothelin (ET) is a cytokine involved in the inductive recruitment of Purkinje fibers. ET is produced by proteolytic cleavage of Big-ET by ECE. We generated an antibody against chick ECE recognizing a single band at approximately 70 kD to correlate the cardiac expression of this protein with that reported previously for its mRNA. ECE protein expression was more widespread compared to its mRNA, being present in endothelial cells, mesenchymal cells, and myocytes, and particularly enriched in the trabeculae and nascent ventricular conduction system. The myocardial expression was significantly modified under experimentally altered hemodynamic loading. In vivo, ET receptor blockade ...
- The spatiotemporal distribution of the endothelin-converting enzyme (ECE) protein in the embryonic chick heart and the association of this polypeptide with the developing cardiac conduction system is described here for the first time. Further, we show how cardiac hemodynamic load directly affects ECE level and distribution. Endothelin (ET) is a cytokine involved in the inductive recruitment of Purkinje fibers. ET is produced by proteolytic cleavage of Big-ET by ECE. We generated an antibody against chick ECE recognizing a single band at approximately 70 kD to correlate the cardiac expression of this protein with that reported previously for its mRNA. ECE protein expression was more widespread compared to its mRNA, being present in endothelial cells, mesenchymal cells, and myocytes, and particularly enriched in the trabeculae and nascent ventricular conduction system. The myocardial expression was significantly modified under experimentally altered hemodynamic loading. In vivo, ET receptor blockade ... (en)
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| Title
| - Cardiac expression patterns of endothelin-converting enzyme (ECE): Implications for conduction system development
- Exprese endothelin-konvertujícího enzymu v srdci: implikace pro vývoj převodního systému (cs)
- Cardiac expression patterns of endothelin-converting enzyme (ECE): Implications for conduction system development (en)
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| skos:prefLabel
| - Cardiac expression patterns of endothelin-converting enzyme (ECE): Implications for conduction system development
- Exprese endothelin-konvertujícího enzymu v srdci: implikace pro vývoj převodního systému (cs)
- Cardiac expression patterns of endothelin-converting enzyme (ECE): Implications for conduction system development (en)
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| skos:notation
| - RIV/67985904:_____/08:00316957!RIV09-AV0-67985904
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA304/08/0615), Z(AV0Z50450515), Z(MSM0021620806)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/67985904:_____/08:00316957
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - chick embryo; heart development; immunohistochemistry (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Sedmera, David
- Zhang, N.
- Gourdie, R. G.
- Grant, E.
- Harris, B. S.
- Jourdan, J.
- Kurková, D.
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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