About: Voltammetric determination of leucovorin using silver solid amalgam electrode

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The voltammetric behavior of leucovorin (LV), as an important and stable reduced metabolite of folic acid, has been investigated on polished (p-AgSAE) and mercury meniscus modified (m-AgSAE) silver solid amalgam electrodes in this paper. LV, after its reverse electrochemical oxidation, can be reduced in two reduction steps in an acidic medium on both electrodes used. The first reduction peak (E-p = -400 mV) can be used for determination of LV. Differential Pulse Voltammetry (DPV) was applied for monitoring voltammetric behavior of LV on both working electrodes. Elimination voltammetry with linear scan was applied for elucidation of the reaction mechanisms. The limits of detection were calculated as 2.2 x 10(-8) mol L-1 (t(acc) = 60 s) for m-AgSAE and 5.0 x 10(-8) mol L-1 (t(acc) = 100 s) for p-AgSAE. The proposed method was applied for LV determination in the pharmaceutical preparation which has been commonly used during methotrexate therapy. The voltammetric behavior of leucovorin (LV), as an important and stable reduced metabolite of folic acid, has been investigated on polished (p-AgSAE) and mercury meniscus modified (m-AgSAE) silver solid amalgam electrodes in this paper. LV, after its reverse electrochemical oxidation, can be reduced in two reduction steps in an acidic medium on both electrodes used. The first reduction peak (E-p = -400 mV) can be used for determination of LV. Differential Pulse Voltammetry (DPV) was applied for monitoring voltammetric behavior of LV on both working electrodes. Elimination voltammetry with linear scan was applied for elucidation of the reaction mechanisms. The limits of detection were calculated as 2.2 x 10(-8) mol L-1 (t(acc) = 60 s) for m-AgSAE and 5.0 x 10(-8) mol L-1 (t(acc) = 100 s) for p-AgSAE. The proposed method was applied for LV determination in the pharmaceutical preparation which has been commonly used during methotrexate therapy. (en)
Title	Voltammetric determination of leucovorin using silver solid amalgam electrode Voltammetric determination of leucovorin using silver solid amalgam electrode (en)
skos:prefLabel	Voltammetric determination of leucovorin using silver solid amalgam electrode Voltammetric determination of leucovorin using silver solid amalgam electrode (en)
skos:notation	RIV/61388955:_____/12:00375916!RIV13-GA0-61388955
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GAP206/11/1638), P(IAA400400806), S, Z(AV0Z40400503)
http://linked.open...iv/cisloPeriodika	JAN 2012
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Navrátil, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav fyzikální chemie J. Heyrovského AV ČR, v.v.i.
http://linked.open...dnocenehoVysledku	178545
http://linked.open...ai/riv/idVysledku	RIV/61388955:_____/12:00375916
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	leucovorin; voltammetry; amalgam electrode (en)
http://linked.open.../riv/klicoveSlovo	amalgam electrode voltammetry leucovorin
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[74F749E52784]
http://linked.open...i/riv/nazevZdroje	Electrochimica acta
http://linked.open...in/vavai/riv/obor	CG
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Novel electrochemical sensors and sensing techniques for the analysis of nucleic acids structure and interactions Transport of Charged and Uncharged Species across Models of Biological Membranes
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	60
http://linked.open...iv/tvurceVysledku	Navrátil, Tomáš Bandžuchová, L. Chýlková, J. Šelešovská, R.
http://linked.open...ain/vavai/riv/wos	000300142100052
http://linked.open...n/vavai/riv/zamer	Struktura, reaktivita a dynamika molekulárních a biomolekulárních systémů: teorie, experiment, aplikace
issn	0013-4686
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.electacta.2011.11.071

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