About: Inactivation of Prions Using Electrical DC Discharges at Atmospheric Pressure and Ambient Temperature

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The ability of DC discharges to inactivate infectious prions was studied using prion cell infectivity assays and direct Western blot analysis of abnormal prion protein. The negative corona discharge of the point-to-plane type significantly decreased prion infectivity of mouse RML scrapie brain homogenates within 20 min of exposure. The positive discharge treated liquids display persistent cidal effect, which kills the cell culture and makes it impossible to assess the presence of prions by the cell infectivity assay. The point-to-point and 'cometary' discharges exhibit only a low ability to inactivate infectious prions. As a possible mechanism of prion inactivation, the formation of insoluble and non-infective high molecular weight complexes is suggested. The ability of DC discharges to inactivate infectious prions was studied using prion cell infectivity assays and direct Western blot analysis of abnormal prion protein. The negative corona discharge of the point-to-plane type significantly decreased prion infectivity of mouse RML scrapie brain homogenates within 20 min of exposure. The positive discharge treated liquids display persistent cidal effect, which kills the cell culture and makes it impossible to assess the presence of prions by the cell infectivity assay. The point-to-point and 'cometary' discharges exhibit only a low ability to inactivate infectious prions. As a possible mechanism of prion inactivation, the formation of insoluble and non-infective high molecular weight complexes is suggested. (en)
Title	Inactivation of Prions Using Electrical DC Discharges at Atmospheric Pressure and Ambient Temperature Inactivation of Prions Using Electrical DC Discharges at Atmospheric Pressure and Ambient Temperature (en)
skos:prefLabel	Inactivation of Prions Using Electrical DC Discharges at Atmospheric Pressure and Ambient Temperature Inactivation of Prions Using Electrical DC Discharges at Atmospheric Pressure and Ambient Temperature (en)
skos:notation	RIV/60461373:22340/11:43891837!RIV12-MSM-22340___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA310/08/0878), P(GP310/09/P260), Z(MSM0021620806), Z(MSM6046137306)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Scholtz, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	204060
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/11:43891837
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	PrP(TSE; prions; prion cell; non-thermal plasma; infectivity assay; corona discharge (en)
http://linked.open.../riv/klicoveSlovo	PrP(TSE infectivity assay prion cell prions corona discharge non-thermal plasma
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[B0A0E8378337]
http://linked.open...i/riv/nazevZdroje	Plasma Processes and Polymers
http://linked.open...in/vavai/riv/obor	BL
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Cell culture for propagation of prions: influence of cell culture proliferation and expression of endogenous retroviruses The role of cellular prion protein in erythroid differentiation: possible link to peripheral pathogenesis of prion diseases
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	8
http://linked.open...iv/tvurceVysledku	Holada, Karel Julák, Jaroslav Scholtz, Vladimír Janoušková, Olga
http://linked.open...ain/vavai/riv/wos	000289999200005
http://linked.open...n/vavai/riv/zamer	Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů Reakčně-transportní chemicko-inženýrské systémy a jejich dynamické chování, modelování a řízení chemických a biotechnologických procesů
issn	1612-8850
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/ppap.201000100
http://localhost/t...ganizacniJednotka	22340

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