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rdf:type
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Description
| - Byly studovány dimery tvořené dvěma oligo-N-methylpyrrolovými peptidy spojenými methano[1,5]diazocinovým strukturním motivem, a to v rcemické i chirální formě. Jejich interakce s DNA byla zkoumána pro DNA z telecího brzlíku, poly(dA-dT)2 a poly(dC-dG)2, a sice pomocí spektroskopie NMR a ECD a pomocí fluorescenčního značení. Zkoumané dimery preferují interakci se sekvencemi AT, ale vykazují vyšší afinitu k poly(dC-dG)2 než distamycin A. Konfigurace (4R,9R) na methanodiazocinovém můstku je vhodnější pro interakci s DNA z telecího brzlíku a poly(dA-dT)2 než konfigurace (4S,9S). (cs)
- %22Head-to -head%22 oligo-N-methylpyrrole peptide dimers linked by a methano[1,5]diazocin scaffold are presented in racemic as well as chiral fashion. Their DNA binding activities were assayed on calf thymus DNA, poly(dA-dT)2 and poly(dC-dG)2 by NMR and ECD spectroscopies. and fluorescence probe displacement assay. The presented dimers prefer AT sequences, but show higher affinity to poly(dC-dG)2 than distamycin A. The (4R,9R) configuration of methanodiazocin bridge was found to be better suited for interaction with ct-DNA and poly(dA-dT)2 than (4S,9S) configuration.
- %22Head-to -head%22 oligo-N-methylpyrrole peptide dimers linked by a methano[1,5]diazocin scaffold are presented in racemic as well as chiral fashion. Their DNA binding activities were assayed on calf thymus DNA, poly(dA-dT)2 and poly(dC-dG)2 by NMR and ECD spectroscopies. and fluorescence probe displacement assay. The presented dimers prefer AT sequences, but show higher affinity to poly(dC-dG)2 than distamycin A. The (4R,9R) configuration of methanodiazocin bridge was found to be better suited for interaction with ct-DNA and poly(dA-dT)2 than (4S,9S) configuration. (en)
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Title
| - Tröger's base scaffold in racemic and chiral fashion as a spacer for bisdistamycin formation. Synthesis and DNA binding study
- Tröger's base scaffold in racemic and chiral fashion as a spacer for bisdistamycin formation. Synthesis and DNA binding study (en)
- Použití racemických a chirálních Trögerových bazí pro syntézu distamycinu. Syntéza a studie interakce s DNA (cs)
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skos:prefLabel
| - Tröger's base scaffold in racemic and chiral fashion as a spacer for bisdistamycin formation. Synthesis and DNA binding study
- Tröger's base scaffold in racemic and chiral fashion as a spacer for bisdistamycin formation. Synthesis and DNA binding study (en)
- Použití racemických a chirálních Trögerových bazí pro syntézu distamycinu. Syntéza a studie interakce s DNA (cs)
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skos:notation
| - RIV/60461373:22340/06:00020163!RIV09-MZ0-22340___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA203/06/1038), P(GA305/05/2030), P(LC512), P(NR8355), R, Z(AV0Z50040507)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/60461373:22340/06:00020163
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Tröger's base; distamycin dimer; enantioselective binding; dissymmetry factor; VCD (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Král, Vladimír
- Tkadlecová, Marcela
- Malina, Jaroslav
- Urbanová, Marie
- Valík, Martin
- Palivec, Lukáš
- Vrabec, Viktor
- Foltýnová, Jarmila
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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