About: Topography of genetic elements of X-chromosome relative to the cell nucleus and to the chromosome X territory determined for human lymphocytes

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About: Topography of genetic elements of X-chromosome relative to the cell nucleus and to the chromosome X territory determined for human lymphocytes Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Topography of three genetic elements - dystrophin (dmd) exons 5-7 (E-1), 46-47 (E-2) and centromere of chromosome X (N-x) were studied relative to cell nuclei and to chromosome X territories of spatially fixed human lymphocytes. Repeated three-dimensional (3D) dual color fluorescence in situ hybridization combined with high-resolution cytometry was used. In addition, the nuclear location of fluorescence weight centers (FWC), spatial volume, and maximal area per one section of chromosome-X territories were investigated. The larger (X-L) and smaller (X-s) homologous X-chromosomes were distinguished for each nucleus according to the 3D volume of their territories. The distributions of the [center of nucleus]-to-[genetic element] distances (radial distributions) of dmd exons E-1, E-2, centromere N-x and FWC were very similar for both homologous X-chromosomes of female lymphocytes as well as for the chromosome X of the human male. Topography of three genetic elements - dystrophin (dmd) exons 5-7 (E-1), 46-47 (E-2) and centromere of chromosome X (N-x) were studied relative to cell nuclei and to chromosome X territories of spatially fixed human lymphocytes. Repeated three-dimensional (3D) dual color fluorescence in situ hybridization combined with high-resolution cytometry was used. In addition, the nuclear location of fluorescence weight centers (FWC), spatial volume, and maximal area per one section of chromosome-X territories were investigated. The larger (X-L) and smaller (X-s) homologous X-chromosomes were distinguished for each nucleus according to the 3D volume of their territories. The distributions of the [center of nucleus]-to-[genetic element] distances (radial distributions) of dmd exons E-1, E-2, centromere N-x and FWC were very similar for both homologous X-chromosomes of female lymphocytes as well as for the chromosome X of the human male. (en)
Title	Topography of genetic elements of X-chromosome relative to the cell nucleus and to the chromosome X territory determined for human lymphocytes Topography of genetic elements of X-chromosome relative to the cell nucleus and to the chromosome X territory determined for human lymphocytes (en)
skos:prefLabel	Topography of genetic elements of X-chromosome relative to the cell nucleus and to the chromosome X territory determined for human lymphocytes Topography of genetic elements of X-chromosome relative to the cell nucleus and to the chromosome X territory determined for human lymphocytes (en)
skos:notation	RIV/00216224:14330/02:00006556!RIV11-AV0-14330___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA202/01/0197), P(GA301/01/0186), P(IBS5004010), P(NC5955), Z(AV0Z5004920)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kozubek, Michal Kozubek, Stanislav Falk, Martin Lukášová, Emilie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	667114
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/02:00006556
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	nuclear architecture; chromosome X inactivation; three dimensional fluorescence in situ hybridization; confocal microscopy; chromatin; condensation (en)
http://linked.open.../riv/klicoveSlovo	chromatin condensation confocal microscopy nuclear architecture chromosome X inactivation three dimensional fluorescence in situ hybridization
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[115EC907237C]
http://linked.open...i/riv/nazevZdroje	Gene
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Investigation of the local control of gene expression using spectral microscopy and omage analysis techniques How the study spatial order of specific genetic loci in nuclei of healthy and malignant tissues can contribute to the diagnostics and treatment of solid tumors. Ionising radiation as a tool in the investigations of the cell nuclear structure and in the development of new techniques for ecology and medicine Development of new diagnostic techniques for oncology
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	292
http://linked.open...iv/tvurceVysledku	Kozubek, Stanislav Lukášová, Emilie Falk, Martin Kozubek, Michal
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors
issn	0378-1119
number of pages	12 (xsd:int)
http://localhost/t...ganizacniJednotka	14330

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