About: The influence of the cell cycle, differentiation and irradiation on the nuclear location of the ABL, BCR and C-MYC genes in human leukemic cells

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About: The influence of the cell cycle, differentiation and irradiation on the nuclear location of the ABL, BCR and C-MYC genes in human leukemic cells Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	abl and bcr genes play an important role in the diagnostics of chronic myelogenous leukemia (CML). The translocation of these genes results in an abnormal chromosome 22 called the Philadelphia chromosome (Ph). The chimeric bcr-abl gene is a fundamental phenomenon in the pathogenesis of CML. Malignant transformation of hematopoietic cells is also accompanied by the c-myc gene changes (translocation, amplification). Nuclear topology of the abl, bcr and c-myc genes was determined in differentiated as well as in irradiated HL-60 cells using dual-color fluorescence in situ hybridisation and image analysis by means of a high resolution cytometer. After the induction of the granulocytic differentiation of HL-60 cells with all trans retinoic acid (ATRA) or dimethylsulfoxide (DMSO), the abl and bcr homologous genes were repositioned closer to the nuclear periphery and the average distances between homologous abl-abl and bcr-bcr genes as well as between heterologous abl-bcr genes were elongated. abl and bcr genes play an important role in the diagnostics of chronic myelogenous leukemia (CML). The translocation of these genes results in an abnormal chromosome 22 called the Philadelphia chromosome (Ph). The chimeric bcr-abl gene is a fundamental phenomenon in the pathogenesis of CML. Malignant transformation of hematopoietic cells is also accompanied by the c-myc gene changes (translocation, amplification). Nuclear topology of the abl, bcr and c-myc genes was determined in differentiated as well as in irradiated HL-60 cells using dual-color fluorescence in situ hybridisation and image analysis by means of a high resolution cytometer. After the induction of the granulocytic differentiation of HL-60 cells with all trans retinoic acid (ATRA) or dimethylsulfoxide (DMSO), the abl and bcr homologous genes were repositioned closer to the nuclear periphery and the average distances between homologous abl-abl and bcr-bcr genes as well as between heterologous abl-bcr genes were elongated. (en)
Title	The influence of the cell cycle, differentiation and irradiation on the nuclear location of the ABL, BCR and C-MYC genes in human leukemic cells The influence of the cell cycle, differentiation and irradiation on the nuclear location of the ABL, BCR and C-MYC genes in human leukemic cells (en)
skos:prefLabel	The influence of the cell cycle, differentiation and irradiation on the nuclear location of the ABL, BCR and C-MYC genes in human leukemic cells The influence of the cell cycle, differentiation and irradiation on the nuclear location of the ABL, BCR and C-MYC genes in human leukemic cells (en)
skos:notation	RIV/00216224:14330/00:00001821!RIV/2002/GA0/143302/N
http://linked.open.../vavai/riv/strany	233
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA202/97/0874), P(GA202/98/P253), P(NM15), Z(MSM 143300002)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2002
http://linked.open...aciTvurceVysledku	Kozubek, Michal Gajdušková, Pavla Bártová, Eva Kozubek, Stanislav Rosenbergová, Kateřina Lukášová, Emilie Skalníková, Magdalena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	713599
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/00:00001821
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	The influence of the cell cycle, differentiation and irradiation on the nuclear location of the ABL, BCR and C-MYC genes in human leukemic cells (en)
http://linked.open.../riv/klicoveSlovo	BCR and C-MYC genes in human leukemic cells The influence of the cell cycle differentiation and irradiation on the nuclear location of the ABL
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[CD398629B17F]
http://linked.open...i/riv/nazevZdroje	Leukemia Research
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	The structure of interphase nucleus and its changes after irradiation Changes in the structure of interphase nucleai of human leukemic cell lines after treatment with differentiating agents and gama irradiation The use interphase FISH for the determination of individuals with elevated risk of the induction of hemoblastoses
http://linked.open...UplatneniVysledku	2000
http://linked.open...v/svazekPeriodika	24
http://linked.open...iv/tvurceVysledku	Bártová, Eva Kozubek, Stanislav Lukášová, Emilie Kozubek, Michal Skalníková, Magdalena Jirsová, Pavla Buchníčková, Kateřina
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20143300002
issn	0145-2126
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	14330

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