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Description
| - The objectives of our study were to analyse the frequency and functional status of HIV-specific CD8+ T cells and the expression of non-specific activation markers on CD8+ T cells in HIV+ patients. We examined 28 HIV+ patients, including 13 patients not receiving therapy complex antiretroviral therapy (cART) using ELISpot assay and flow cytometry with intracellular and MHC tetramer staining. The results suggested that the alterations of HIV-specific immunity are not influenced by the therapy of HIV infection; whereas, the non-specific chronic immune activation is down-regulated by cART.
- The objectives of our study were to analyse the frequency and functional status of HIV-specific CD8+ T cells and the expression of non-specific activation markers on CD8+ T cells in HIV+ patients. We examined 28 HIV+ patients, including 13 patients not receiving therapy complex antiretroviral therapy (cART) using ELISpot assay and flow cytometry with intracellular and MHC tetramer staining. The results suggested that the alterations of HIV-specific immunity are not influenced by the therapy of HIV infection; whereas, the non-specific chronic immune activation is down-regulated by cART. (en)
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Title
| - Antiretroviral treatment of HIV infection does not influence HIV-specific immunity but has an impact on Non-specific immune activation
- Antiretroviral treatment of HIV infection does not influence HIV-specific immunity but has an impact on Non-specific immune activation (en)
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skos:prefLabel
| - Antiretroviral treatment of HIV infection does not influence HIV-specific immunity but has an impact on Non-specific immune activation
- Antiretroviral treatment of HIV infection does not influence HIV-specific immunity but has an impact on Non-specific immune activation (en)
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skos:notation
| - RIV/00064211:_____/11:#0000165!RIV14-MZ0-00064211
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - I, P(GD310/05/H533), S, Z(MSM0021620806)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00064211:_____/11:#0000165
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Antiretroviral therapy; CD38; HIV infection; HIV-specific CD8+ T cells; HLA-DR; Multifunctional CD8+ T cells (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Bartovská, Zofia
- Beran, Ondřej
- Holub, Michal
- Rozsypal, Hanuš
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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