About: Role of lipid rafts in regulation of cell signalling leading to modulation of cytokinetics of cancer cells

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About: Role of lipid rafts in regulation of cell signalling leading to modulation of cytokinetics of cancer cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=MEB040703
Description	A number of studies, including our own preliminary data, have shown that TRAIL (an important member of the TNF family) works synergistically with some anticancer drugs to kill most types of tumor cells and reversed resistance to such drugs. These findings indicate that the combination of TRAIL and chemotherapeutic drugs is potentially promising in treating refractory cancers. TRAIL can induce human cancer cell apoptosis through engagement of its death receptors DR4 and DR5. However, not all cancers are sensitive to this cytokine. Recently, it was shown that low doses of cytotoxic drugs could restore TRAIL-induced cell death in resistant colon and prostate cancer cell lines. Taken together, finding mechanisms leading to sensitizing the cancer cells to chemotherapy represent a useful approach for identifying new and/or improving existing anti-cancer strategies. The general aims of the proposal are 1) To identify if and how the treatment of the cells by DHA modulate association of selected death recep (en) A number of studies, including our own preliminary data, have shown that TRAIL (an important member of the TNF family) works synergistically with some anticancer drugs to kill most types of tumor cells and reversed resistance to such drugs. These findings indicate that the combination of TRAIL and chemotherapeutic drugs is potentially promising in treating refractory cancers. TRAIL can induce human cancer cell apoptosis through engagement of its death receptors DR4 and DR5. However, not all cancers are sensitive to this cytokine. Recently, it was shown that low doses of cytotoxic drugs could restore TRAIL-induced cell death in resistant colon and prostate cancer cell lines. Taken together, finding mechanisms leading to sensitizing the cancer cells to chemotherapy represent a useful approach for identifying new and/or improving existing anti-cancer strategies. The general aims of the proposal are 1) To identify if and how the treatment of the cells by DHA modulate association of selected death recep
Title	Role of lipid rafts in regulation of cell signalling leading to modulation of cytokinetics of cancer cells (en) Úloha lipidových raftů v řízení buněčné signalizace vedoucí k modulaci cytokinetiky nádorových buněk
skos:notation	MEB040703
http://linked.open...avai/cep/aktivita	KONTAKT
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/MEB040703/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/MEB040703/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2010-05-07 (xsd:date)
http://linked.open...i/cep/druhSouteze	M2 - Mezinárodní spolupráce podle uzavřených smluv o dvoustranné mezinárodní spolupráci ve VaV
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	69261424
http://linked.open...ai/cep/hlavniObor	ED - Fyziologie
http://linked.open...hodnoceniProjektu	U - Uspěl podle zadání, tj. byly splněny cíle a jeho předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory
http://linked.open...vai/cep/kategorie	ZV - Základní výzkum
http://linked.open.../cep/klicovaSlova	cancer- cell signalling- lipid rafts- TRAIL- cisplatin- colocalization- FRET- cytometry- (en)
http://linked.open...ep/partnetrHlavni	Biofyzikální ústav AV ČR, v.v.i.
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open.../pocetVysledkuRIV	0 (xsd:int)
http://linked.open...enychVysledkuVRIV	0 (xsd:int)
http://linked.open...lneniVMinulemRoce	2008-08-13 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/6078%2F2008-32
http://linked.open...iciPoslednihoRoku	2008
http://linked.open...atUdajeProjZameru	2009
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open...ep/ukonceniReseni	2008-12-31 (xsd:date)
http://linked.open...ep/zahajeniReseni	2008-01-01 (xsd:date)
http://linked.open...jektu+dodavatelem	The main contribution was on the methodological level. The results demonstrated that Pt-cytostatics may modulate signalling of TRAIL by different mechanisms - changes of cell membrane, expression of receptors and kinetics of internalization of TRAIL. (en) Hlavní přínos byl v oblasti metodologické. Dále výsledky ukázaly, že Pt-cytostatika mohou modulovat signální dráhu TRAIL pomocí řady různých mechanismů, které zahrnují změny na úrovni buněčné membrány, exprese receptorů i kinetiky internalizace TRAIL. (cs)
http://linked.open...tniCyklusProjektu	JU
is http://linked.open...vavai/cep/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/MEB040703/2008/ico%3A68081707 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/MEB040703/2009/ico%3A68081707

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