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Description
| - Development and application of electrochemical methods and biosensors in studies of nucleic acids structure and interactions and/or in detection of DNA hybridization or damage belongs to the most dynamically developing areas of contemporary science. In this project, we propose to continue the existing fruitful research in the Applicant's and Joint Applicant's laboratories and to obtain new knowledge about the behavior of unmodified and chemically modified nucleic acids, their complexes with low molecular mass genotoxic substances and/or with proteins at different electrodes, including newly introduced types of solid amalgam electrodes. The proposed research will involve detailed studies of electrochemical processes underwent by nucleic acids and their conjugates with electroactive markers at different electrode materials. Electrochemical analysis will be combined with separation techniques and with immunoanalysis to develop new methods of detection of DNA damage, its chemical modification (en)
- Vývoj a využití elektrochemických metod a biosensorů při studiu struktury a interakcí nukleových kyselin a jako nástrojů pro detekci hybridizace DNA a jejího poškození patří k nejdynamičtěji se rozvíjejícím oblastem současné vědy. V rámci tohoto projektunavrhujeme navázat na dosavadní úspěšný výzkum v laboratořích navrhovatele i spolunavrhovatele a získat nové poznatky o chování nemodifikovaných a chemicky modifikovaných nukleových kyselin, jejich komplexů s nízkomolekulárními genotoxickými látkami a s proteiny na různých typech elektrod, včetně nově zavedených typů pevných amalgámových elektrod. Součástí navrhovaného výzkumu je detailní studium elektrochemických procesů, jimž podléhají na elektrodách z různých materiálů nukleové kyseliny a jejich konjugáty s elektroaktivními značkami. Elektrochemická analýza bude kombinována se separačními technikami a s imunoanalýzou, a na základě této kombinace budou vyvíjeny nové metody detekce poškození DNA a její chemické modifikace in vitro i v buňkách, a
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Title
| - Analysis of DNA structure and interactions using electrochemical techniques and chemical probes. Novel techniques and sensors for DNA damage detection (en)
- Analýza struktury a interakcí DNA pomocí elektrochemických technik a chemických sond. Nové metody a senzory pro detekci poškození DNA
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skos:notation
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http://linked.open...avai/cep/aktivita
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http://linked.open...kovaStatniPodpora
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http://linked.open...ep/celkoveNaklady
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http://linked.open...datumDodatniDoRIV
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http://linked.open...i/cep/druhSouteze
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http://linked.open...ep/duvernostUdaju
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http://linked.open.../cep/fazeProjektu
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http://linked.open...ai/cep/hlavniObor
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http://linked.open...hodnoceniProjektu
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http://linked.open...vai/cep/kategorie
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http://linked.open.../cep/klicovaSlova
| - electrochemical analysis; DNA damage; genotoxic agents; interactions; DNA structure; chemical probes (en)
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http://linked.open...ep/partnetrHlavni
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http://linked.open...inujicichPrijemcu
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http://linked.open...cep/pocetPrijemcu
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http://linked.open...ocetSpoluPrijemcu
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http://linked.open.../pocetVysledkuRIV
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http://linked.open...enychVysledkuVRIV
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http://linked.open...lneniVMinulemRoce
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http://linked.open.../prideleniPodpory
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http://linked.open...iciPoslednihoRoku
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http://linked.open...atUdajeProjZameru
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http://linked.open.../vavai/cep/soutez
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http://linked.open...usZobrazovaneFaze
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http://linked.open...ai/cep/typPojektu
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http://linked.open...ep/ukonceniReseni
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http://linked.open.../cep/vedlejsiObor
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http://linked.open...ep/zahajeniReseni
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http://linked.open...jektu+dodavatelem
| - . (en)
- Řešení projektu probíhalo zcela bez problémů, bylo dosaženo všech vytčených cílů a o úspěšnosti projektu svědčí i velmi nadstandardní publikační aktivita řešitelského týmu. Celkově lze řešení projektu hodnotit jako vynikající. (cs)
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http://linked.open...tniCyklusProjektu
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http://linked.open.../cep/klicoveSlovo
| - electrochemical analysis
- DNA damage
- DNA structure
- genotoxic agents
- interactions
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is http://linked.open...vavai/riv/projekt
of | - Aminophenyl- and nitrophenyl-labeled nucleoside triphosphates. Synthesis, enzymatic incorporation and electrochemical detection
- A Multisensor for Electrochemical Sequential Autonomous Automatic Measurements
- Voltammetric Determination of Picric Acid using Silver Amalgam Paste Electrode and Carbon Paste Electrode
- Voltammetric Determination of 4-Nitrophenol and 5-Nitrobenzimidazole on Different Amalgam Electrodes
- Voltametrické stanovení herbicidu Bifenoxu na rtuťovým meniskem modifikované pevné stříbrné amalgámové elektrodě
- The Use of Silver Solid Amalgam Working Electrode for Determination of Nitrophenols by HPLC with Electrochemical Detection
- Vlastnosti pevných a pastových amalgámových pracovních elektrod odlišné od elektrod z kovové rtuti
- Determination of trans-Resveratrol on Carbon Paste Electrode
- Differential Pulse Voltammetric Determination of Selected Nitro-Compounds on Silver, Solid Silver Composite, and Solid Graphite Composite Electrodes
- Enzyme-linked electrochemical detection of PCR-amplified nucleotide sequences using disposable screen-printed sensors. Applications in gene expression monitoring
- Cross-coupling reactions of nucleoside triphosphates followed by polymerase incorporation. Construction and applications of base-functionalized nucleic acids
- Elektrochemické rozpouštěcí metody pro speciaci olova a kadmia v půdních roztocích
- Sensitive voltammetric detection of DNA damage at carbon electrodes using DNA repair enzymes and an electroactive osmium marker
- Magnetické mikročástice ve spojení s elektrochemickou analýzou jako mnohostranně využitelné nástroje pro analýzu biomolekulárních interakcí
- Novel base-functionalized DNA. Efficient methodology for construction and bioanalytical applications
- Label-free electrochemical monitoring of DNA ligase activity
- Electrochemical stripping techniques in analysis of nucleic acids and their constituents
- Interaction of biomacromolecules with surfaces viewed by electrochemical methods
- Detection of abasic sites in DNA by electrochemical, immunoelectrochemical and acoustic methods using OsO4, 2,2,-bipyridine as a probe for unpaired thymine residues
- Base-modified DNA labeled by [Ru(bpy)3]2+ and [Os(bpy)3]2+ complexes: construction by polymerase incorporation of modified nucleoside triphosphates, electrochemical and luminescent properties, and applications
- Improved electrochemical detection of purine nucleobases at mechanically roughened edge-plane pyrolytic graphite electrode
- Improved sensitivity and selectivity of uric acid voltammetric sensing with mechanically grinded carbon/graphite electrodes
- Simultaneous electrochemical monitoring of metabolites related to the xanthine oxidase pathway using a grinded carbon electrode
- Detection of single nucleotide polymorphisms in p53 mutation hotspots and expression of mutant p53 in human cell lines using an enzyme-linked electrochemical assay
- Ex situ voltammetry and chronopotentiometry of doxorubicin at a pyrolytic graphite electrode: Redox and catalytic properties and analytical applications
- The reduction of doxorubicin at a mercury electrode and monitoring its interaction with DNA using constant current chronopotentiometry
- Preparation and Properties of Mercury Film Electrodes on Solid Amalgam Surface
- Elektrochemické studium vlivu dlouhodobé suplementace kreatinu na lidský metabolismus
- Voltammetric Determination of Nitrophenols at a Silver Solid Amalgam Electrode
- Role velikosti proudu v rozpouštěcí chronopotenciometrii
- Pracovní elektrody z pastových amalgámů
- Přínos chronopotenciometrie stálým proudem pro bioelektrochemii
- Stanovení herbicidu dinosebu na amalgamových a uhlíkových elektrodách
- Kompozitní pevné amalgámové elektrody
- Využití prototypu multikanálového přístroje pro elektrochemickou detekci hybridizace DNA
- Interaction of creatine metabolism with three possible enzymatic pathways using homocysteine
- The effect of supraphysiological doses of creatine on homocysteine metabolism in sportsmen
- Application of Modern Electrochemical Techniques and Electrode Materials in Determination of Trace Elements in Environment
- Non-traditional metal electrode materials in electrochemical nvironmental analysis of biologically active compounds
- Potential Fallouts of Accidental Ingestion of Limescale Removers
- Oxidizability of cysteine and short cysteine-containing peptides by molecular oxygen
- Solid Amalgam Composite Electrode as a New Sensor for the Determination of Biologically Active Compounds
- Application of elimination voltammetry to the study of electrochemical reduction and determination of the herbicide metribuzin
- Jaký je význam vápníku pro léčbu osteoporózy?
- Application of modern electrochemical techniques and electrode materials in determination of trace elements in environment
- Kompozitní amalgámové elektrody
- Adsorption of oligonucleotides A10, A25, A50 and A80 at the mercury/electrolyte interface.
- Electrochemical Sensing of Chromium-Induced DNA Damage: DNA Strand Breakage by Intermediates of Chromium(VI) Electrochemical Reduction.
- Carbone paste electrodes for the determination of detrimental substances in drinking water
- New electrode materials for determination of genotoxic substances
- Novel type of silver amalgam paste electrode
- Utilization of silver solid amalgam electrode for amperometric determination of plant growth regulator by HPLC-ED
- Two-dimensional condensation of pyrimidine oligonucleotides during their self-assemblies at mercury based surfaces.
- Label-free sequence-specific DNA sensing using copper-enhanced anodic stripping of purine bases at boron-doped diamond electrodes
- Monitoring of in vitro DNA synthesis and PCR amplification using 7-deaza-purines as electroactive markers
- Voltammetric determination of the herbicide Bifenox in drinking and river water using a silver solid amalgam electrode
- Electrochemical Detection of Cadmium and Lead Complexes with Low Molecular Weight Organic Acids
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