About: Proteomic identification of biomarkers of intraamniotic inflammation in amniotic fluid in preterm birth patients     Goto   Sponge   NotDistinct   Permalink

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  • Intraamniotic inflammation has been demonstrated to be associated with a significantly increased rate of neonatal adverse outcome, even in the absence of demonstrable positive cultures. The biochemical and protein composition of amniotic fluid is altered during pregnancy and reflects both physiological as well as pathological changes in the fetomaternal compartment. Modern proteomic technologies are able to detect and characterize even the slightest changes in protein composition of various biological matrices. In the proposed project, we are going to use a combination of multidimensional liquid chromatography separation with subsequent tandem mass spectrometric analyzes. Thanks to the ability to both identify and quantify a large number of proteins, this approach seems to be a very promising one for the detection of changes in amniotic fluid protein composition. Characterization of the human AF proteome represents a crucial step toward the subsequent study of aberrant protein expression and the ide (en)
  • Primárním cílem projektu je pomocí moderních nástrojů proteomiky charakterizovat rozdíly v proteinovým složením plodové vody u pacientek se spontánním předčasným porodem v gestačním stáří mezi 24+0 až 36+6 s přítomnosti či absencí intraamniálního zánětu.
Title
  • Proteomic identification of biomarkers of intraamniotic inflammation in amniotic fluid in preterm birth patients (en)
  • Proteomická identifikace biomarkerů intraamniálního zánětu v plodové vodě pacientek se spontánním předčasným porodem
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  • ME10025
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  • proteomics; intraamniotic inflammation; amniotic fluid (en)
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  • S využitím globálních proteomických a cílených analýz jsme u pacientek se spontánním předčasným porodem mezi 24. a 37. týdnem těhotenství charakterizovali změny v proteomu plodové vody z konce první doby porodní, ke kterým dochází na podkladě mikrobiální invaze do amniální dutiny a histologické chorioamnionitidy. (cs)
  • With using unbiased and hypothesis-driven approaches, we analyzed amniotic fluid obtained at the end of the first stage of from women with spontaneous preterm birth between gestational ages 24 and 37 weeks to characterize proteome-wide changes associated with microbial invasion of the amniotic cavity and histological chorioamnionitis. (en)
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  • proteomics
  • intraamniotic inflammation
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