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  • Novel meningococcal vaccines designed using reverse vaccinology methods will be analyzed for the suitability for use in the Czech Republic (CR) to prevent serogroup B invasive meningococcal disease and non-B serogroup invasive meningococcal disease and for efficacy in inducing herd immunity in the non-vaccinated population. Molecular biological methods will be used for the study of the GNA (Genome-derived Neisserial Antigens) genes GNA1870, GNA1994, GNA1030, GNA2091 and GNA2132. N. meningitidis will also be characterized by molecular methods (MLST, and PorA, FetA and PenA sequencing). The obtained molecular typing data will be submitted to the international sequence data bases. The obtained background data will be relevant to deciding whether novel vaccines are suitable for use in CR and to updating the meningococcal vaccination strategy guidelines for the Ministry of Health. (en)
  • "V projektu bude studováno, zda nové meningokokové vakcíny vyrobené ve světě metodami reverzní vakcinologie jsou vhodné k použití v České republice k prevenci invazivního meningokokového onemocnění způsobeného séroskupinou B, k prevenci ""non-B"" invazivního meningokokového onemocnění a zda budou vyvolávat kolektivní imunitu i u nevakcinované části populace. Metodami molekulární biologie budou studovány geny GNA (Genome-derived Neisserial Antigens) Neisseria meningitidis: GNA1870, GNA1994, GNA1030, GNA2091 a GNA2132. Kromě studia GNA bude prováděna molekulární charakterizace N. meningitidis (MLST, sekvenace PorA, FetA a PenA). Zjištěné molekulární charakterizace meningokoků budou hlášeny do mezinárodních databází. Výsledky projektu budou podkladem k rozhodnutí o vhodnosti nových meningokokových vakcín pro Českou republiku a k aktualizaci antimeningokokové vakcinační strategie předkládané MZ ČR." (cs)
Title
  • Study of the usability of meningococcal vaccines designed using reverse vaccinology methods in the Czech Republic (en)
  • Studium vhodnosti použití v ČR meningokokových vakcín vyrobených metodami reverzní vakcinologie (cs)
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  • meningococcal vaccine; reverse vaccinology; Genome-derived Neisserial Anti; vaccination strategy (en)
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