About: Expression of the c-kit protein, EGFR, and HER-2/neu in high grade carcinomas of salivary gland: prognostic or predictive markers?     Goto   Sponge   NotDistinct   Permalink

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  • The aims of project is to study in retrospective histological and immunohistochemical analysis expression of selected biological markers (c-kit, EGFR, and HER-2/neu) in the series of high grade salivary gland carcinomas. It is supposed to find genetic/epigenetic correlations and to associate them with clinical outcomes in patients. Our study is expected to open the way for targeted therapy of some high grade salivary gland carcinomas. (en)
  • Cílem projektu je sledovat imunohistochemicky expresi vybraných onkoproteinů (c-kit, EGFR, a HER-2/neu) v různých typech vysoce maligních salivárních karcinomů a korelovat ji s patomorfologií nádorů a jejich prognózou. Dále budeme vyšetřovat somatické mutace a amplifikace genů kodujících tyto onkoproteiny. Cíle projektu jsou ve shodě s celkovou strategií IGA MZ podporovat projekty zaměřené na včasnou diagnostiku umožňující moderní komplexní terapii zhoubných nádorů. (cs)
Title
  • Expression of the c-kit protein, EGFR, and HER-2/neu in high grade carcinomas of salivary gland: prognostic or predictive markers? (en)
  • Exprese c-kit proteinu, EGFR a HER-2/neu v high grade karcinomech slinných žláz: prognostický nebo prediktivní význam? (cs)
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  • salivary gland; high grade carcinoma; prognosis; targeted therapy; c-kit; HER-2/neu; EGFR; predictive (en)
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