About: The role of increased epoxyeicosatrienoic acids level in the regulation of renal function and pathophysiology of renovascular hypertension     Goto   Sponge   NotDistinct   Permalink

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  • Předmětem této grantové aplikace je ověření zda inhibitory solubilní epoxide hydrolázy (sEH), zvyšující koncentraci epoxyeikosatrienových kyselin (EETs) ve tkáních, mohou představovat potenciálně nový přístup v antihypertenzní terapii. Bude proto testován účinek inhibitoru sEH, cis-4-[4-(3-Adamantan-1-yl-ureido)-cyclohexyl-oxy]-benzoové kyseliny (c-AUCB) na krevní tlak renální funkce a tkáňové poškození ledvin u modelu renovaskulární hypertenze. (cs)
  • This proposal is designed to determine whether inhibitors of soluble epoxide hydrolase (sEH), increasing endogenous level of epoxyeicosatrienoic acids (EETs), could be a potential new approach in antihypertensive drug therapy. An effects of novel sEH inhibitor, cis-4-[4-(3-Adamantan-1-yl-ureido)-cyclohexyl-oxy]-benzoic acid (c-AUCB) on blood pressure, renal function and renal injury will be tested in Goldblatt two kidney one clip (2K1C) rat model of renovascular hypertension. (en)
Title
  • The role of increased epoxyeicosatrienoic acids level in the regulation of renal function and pathophysiology of renovascular hypertension (en)
  • Úloha zvýšených koncentrací epoxyeikosatrienových kyselin v regulaci renálních funkcí a patofyziologii renovaskulární hypertenze (cs)
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  • epoxyeicosatrienoic acids; epoxide hydrolase; renovascular hypertension; renal injury; renal function; antihypertensive therapy (en)
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