About: Individual 5-fluorouracil dose individualization in patients with colorectal cancer     Goto   Sponge   NotDistinct   Permalink

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  • The objective of the research is to verify the potential importance of 5-FU pharmacokinetic characteristics and biomarkers reflecting the genetic polymorphism of enzymes involved the efficacy of the drug. The goal is to predict the drug dose dense regime of i.v. 5-FU administration to patients suffering from colorectal carcinoma in neoadjuvant therapy to ensure the maximum benefit and minimum toxicity. (en)
  • Využití parametrů a biomarkerů charakterizujících enzymatický genetický polymorfismus, kinetické a dynamické vlastnosti 5-fluorouracilu pro výpočet a predikci rychlosti i.v. přívodu léčiva u nemocných s kolorektálním karcinomem. Cílem je optimální terapeutická účinnost za přijatelných rizik nežádoucích a toxických účinků. (cs)
Title
  • Individuální predikce dávkového režimu 5-fluorouracilu v léčbě kolorektálního karcinomu (cs)
  • Individual 5-fluorouracil dose individualization in patients with colorectal cancer (en)
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  • pharmacogenetics; pharmacokinetics; toxicity; pharmacodynamic; prediction; 5-fluorouracil; dose dense regime; colorectal carcinoma (en)
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