About: Interactions between nuclear and nucleolar proteins controlling cell proliferation and apoptosis effectors during leukemogenesis and therapy of leukemias.     Goto   Sponge   NotDistinct   Permalink

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  • Study of interactions between nuclear and nucleolar factors controlling cell proliferation and effectors of programmed cell death. Modifications and translocations during leukemogenesis and drug induced apoptosis in normal leukocytes and leukemic cells. The study of interaction complexes in normal blood cells and leukemic cell lines using: qRT-PCR, immunoblotting, yeast two-hybrid system, affinity chromatography, mass spektrometry, flow cytometry, immunofluorescence microscopy. (en)
  • Interakce mezi regulátory buněčné proliferace a apoptotickými efektory protinádorové obrany v normálních a leukemických buňkách. Změny tvorby a lokalizace interakčních komplexů při vzniku krevních malignit, význam v časné diagnostice a léčbě leukémií. Studium interakčních komplexů v normálních krevních buňkách a v buňkách leukemických linií metodami: imunoblot, afinitní chromatografie, kvasinkový 2-hybridní systém, hmotová spektrometrie, průtoková cytometrie, fluorescenční mikroskopie. (cs)
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  • Interactions between nuclear and nucleolar proteins controlling cell proliferation and apoptosis effectors during leukemogenesis and therapy of leukemias. (en)
  • Interakce mezi nukleárními a nukleolárními regulátory buněčné proliferace a apoptotickými efektory při vzniku, rozvoji a léčbě leukémií (cs)
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  • Leukemia; Nucleus; Nucleolus; Interaction; Oncogene; Tumorsuppressor; Apoptosis; Cytotoxic (en)
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