About: Vectors for gene therapy targeted on stromal cells of solid tumors     Goto   Sponge   NotDistinct   Permalink

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  • Investigation of an anti-tumor therapeutic DNA vaccine and vectors for gene therapy targeting tumor fibroblasts in mouse model of tumors induced by papilloma virus HPV16. DNA vaccine will provide immunization against fibroblast activating protein (FAP). Vaccine will be combined with DNA vaccine specific for viral oncoprotein HPV16-E7. Recombinant vaccinia virus vectors will allow expression of the ectodomain of the human type II TGF-beta receptor genetically fused to the IgG1Fc fragment or the gene for IGFBP-3 (IGF Binding Protein-3). Immunotherapy with DNA vaccines and viral vectors expressing the anti-tumor factors and immune response enhancing cytokines resulting in increase of the anti-tumor mechanisms. (en)
  • Výzkum terapeutické protinádorové DNA vakcíny a vektorů pro genovou terapii zaměřených na nádorové fibroblasty na myším modelu nádorů vyvolaných papilomavirem HPV16. DNA vakcína bude namířena proti fibroblastovému aktivačnímu proteinu (FAP). Vakcína bude podávána v kombinaci s vakcínou specifickou pro onkoprotein HPV16-E7. Virové vektory z viru vakcinie budou v nádorech produkovat ektodoménu receptoru lidského TGF-beta typu II, geneticky fúzovanou k Fc fragmentu IgG1 nebo IGFBP-3 (IGF Binding Protein-3). Kombinovaná terapie zahrnující DNA imunizaci a lokální infekci virovými vektory, jež exprimují blokující faktory a cytokiny zvyšující imunitní odpověď, čímž budou posíleny protinádorové mechanismy, aniž by jednotlivé zásahy interferovaly. (cs)
Title
  • Vektory pro genovou terapii zacílenou na buňky stromatu pevných nádorů (cs)
  • Vectors for gene therapy targeted on stromal cells of solid tumors (en)
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  • Tumor; Cervical carcinoma; IGFBP-3; TGF beta RII; FAP; DNA vaccine; Vaccinia virus; HPV16-E7 (en)
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