About: Genetic Predisposition to Vascular Complications of Type 1 and Type 2 Diabetes Mellitus in Women     Goto   Sponge   NotDistinct   Permalink

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  • The project aims at determining the role of variability of connexin 37 gene in development of micro- and macroangiopathy in females with type 1 or type 2 diabetes mellitus. A secondary target is to determine the effect of menopause on the complications. Female patients (300-350) with type 1 diabetes mellitus and the same number of type 2 diabetes mellitus female patients will be examined. A cohort of 1 000 women from a representative sample of Czech population will be used as a control group. Clinical data and the presence of micro- or macroangiopathy will be assessed. The measurement of ankle-arm, toe-arm blood pressure ratios and intima/media thickness will determine the presence of subclinical atherosclerosis. (en)
  • Cílem našeho projektu je stanovit úlohu variabity genu pro connexin 37 při vzniku mikro- a makroangiopatie u žen s diabetes mellitus 1.a 2. typu. Vedlejší cíl je stanovení vlivu menopauzy na tyto komplikace. Budou vyšetřeny pacientky s diabetes mellitus 1. typu (300-350 osob) a diabetes mellitus 2. typu (300-350 osob). Kontrolní skupinou bude přibližně již 1 000 žen z reprezentativního vzorku české populace. U všech vyšetřených budou zjištěna základní klinická data (trvání a kompenzace diabetes mellitus, přítomnost mikro- či makroangiopatie), ultrazvukem a změřením poměru tlaků kotník/paže či palec/paže bude stanovena přítomnost subklinické aterosklerózy. (cs)
Title
  • Genetická predisposice k cévním komplikacím diabetes mellitus 1. a 2. typu u žen (cs)
  • Genetic Predisposition to Vascular Complications of Type 1 and Type 2 Diabetes Mellitus in Women (en)
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  • Diabetes mellitus; Microangiopathy; Macroangiopathy; Genetics; PCR; Connexin 37 (en)
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