About: Mouse conditional model of chromatin remodeling factor Snf2h inactivation to study its role in hematopoiesis and leukemogenesis

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About: Mouse conditional model of chromatin remodeling factor Snf2h inactivation to study its role in hematopoiesis and leukemogenesis Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

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Description	V této aplikaci navrhuji experimenty ke studiu role Snf2h v normální a leukemické krvetvorbě v myši pomocí vytvoření myšího kmenu, ve kterém Snf2h bude inaktivovatelný kondicionálně ve specifických buněčných typech. Navrhuji dále experimenty zacílené na studium role Snf2h v udržování fentypu leukemických buněk manipulací genové exprese Snf2h v leukemických blastech. (cs) In this application I propose experiments to further investigate the role of Snf2h in normal hematopoiesis and in the development of acute leukemia in mice using conditional knockout model. In this application I also propose experiments to study the role of Snf2h in maintenance of leukemic phenotype in malignant blasts. (en)
Title	Mouse conditional model of chromatin remodeling factor Snf2h inactivation to study its role in hematopoiesis and leukemogenesis (en) Myší model kondicionální inaktivace chromatin remodelačního faktoru Snf2h pro studium jeho role v normální a leukemické krvetvorbě (cs)
http://linked.open...vai/cislo-smlouvy	http://linked.opendata.cz/resource/domain/vavai/cep/smlouva/NR9021-4/2006
http://linked.open...avai/druh-souteze	http://linked.opendata.cz/resource/domain/vavai/cep/druh-souteze/VS
http://linked.open...domain/vavai/faze	http://linked.opendata.cz/resource/domain/vavai/cep/faze/36817172
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http://linked.open...n/vavai/kategorie	http://linked.opendata.cz/resource/domain/vavai/cep/kategorie/21
http://linked.open...vai/klicova-slova	chromatin; transcription; Snf2h; repression; leukemia; knockout model; transgenic model; PU.1 (en)
http://linked.open...avai/konec-reseni	2009-12-31 (xsd:date)
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is http://linked.open...ain/vavai/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2006/NR9021/orjk-11110 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2007/NR9021/orjk-11110 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2008/NR9021/orjk-11110 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2009/NR9021/orjk-11110 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2010/NR9021/orjk-11110

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