About: Thrombotic thrombocytopenic purpura: molecular-biological diagnosis     Goto   Sponge   NotDistinct   Permalink

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  • In our molecular-biological study of diagnosis of TTP we will focus on establisment of assays which determine activity of the vWF cleavage protease and its auto antibody. We shall establish methods for searching of mutation in gene for vWF protease. (ADAMST13) and we will folow up markers of hypercoagulation during a various states of disease. (en)
  • V rámci molekulárně-genetické diagnostiky TTP budeme zavádět metodiky na stanovení aktivity depolymerázy VWF a jejího inhibitoru, metodiky na DNA analýzu genu pro depolymerázu (ADAMST13) a hyperkoagulační ukazatele v průběhu remise i onemocnění. (cs)
Title
  • Molekulárně-biologická diagnostika trombotické trombocytopenické purpury. (cs)
  • Thrombotic thrombocytopenic purpura: molecular-biological diagnosis (en)
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  • TTP;vWF-depolymeraze;ADAMST13;von Willebrand Factor;multimers vWF;TF-bearing microparticles;activation of coagulation;microtrombi (en)
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