About: Study of CFTR gene mutations in chronic pancreatitis,Crohn disease and cancers of oesphagus, small and large intestine and pancreas.

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About: Study of CFTR gene mutations in chronic pancreatitis,Crohn disease and cancers of oesphagus, small and large intestine and pancreas. Goto Sponge NotDistinct Permalink

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Description	Studie p°ispýje k objasnýnÝ patogenetickÚ spolu˙Ŕasti mutacÝ CFTR genu, intragenovřch variant a genetickřch faktor¨, vßzanřch k tomuto genu a objasnýnÝ zvřÜenÚho risika karcinomu jÝcnu, pankreatu, tenkÚho st°eva, prokßzanÚho u dospýlřch pacient¨ s CF. Studie ový°Ý podÝl urŔitÚho typu mutacÝ CFTR genu v patogenese chronickÚ pankreatitidy a Crohnovy choroby v d¨sledku poruch funkce chloridovÚho kanßlu v bunýŔnřch membrßnßch a poruch posttranslaŔnÝ ˙pravy jinřch genovřch produkt¨. (cs) Projectmight elucidate pathogenetic role of CFTR mutations,of intragenic and extragenic polymorfisms in the increased risk of digestive system cancers,revealed in adult cystic fibrosis patients. Significance of CFTR gene mutations in pathogenesis of chronic pancreatitis,Crohn disease,due tothe abnormal chloride channel function of cell membranes and of secondary of posttranslation finishing of other gene products will be verified. (en)
Title	Studium mutací CFTR genu u chronické pankreatitidy,Crohnovy nemoci a karcinomů jícnu, pankreatu,tenkého a tlustého střeva. (cs) Study of CFTR gene mutations in chronic pancreatitis,Crohn disease and cancers of oesphagus, small and large intestine and pancreas. (en)
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